摘要
G蛋白胆汁酸耦联受体（TGR5）是G蛋白耦联受体家族中的一员，也被称之为M—BAR，GPBAR1和GPR131，其不仅参与胆汁酸，糖类、脂类、及能量代谢，还具有肝脏保护功能，对肠道运动具有调节功能。目前研究证实，TGR5可以通过多种途径调节免疫反应，如通过干扰NF-KB活性抑制巨噬细胞的炎症反应等，同时还参与了许多肿瘤、炎症性疾病的发生发展。
G protein-coupled receptor for bile acids （TGR5）, also known as MBAR, GPBAR1, or GPR131, is a member of GPCR （ G-protein coupled receptor） family. It is not only involved in bile acid metab- olism, sugar, lipid and energy metabolism, but also has the function of protecting the liver and regulating intesti- nal movement. Studies have suggested that TGR5 can modulate the immune response through a variety of ways, such as inhibiting inflammatory response of macrophages by interfering with NF-KB activity. TGR5 also partici- pates in the development of various cancers and inflammatory diseases.
出处
《国际免疫学杂志》
CAS
2015年第6期558-560,共3页
International Journal of Immunology
基金
基金项目：国家自然科学基金（81270310）
黑龙江省教育厅海外学人重点项目（1252HQ013）
中国博士后第7批特别资助项目（2014T70365）
于维汉杰出青年基金（3010001000005）
