吲哚胺2，3双加氧酶在乳腺癌中的研究进展

Research progress of IDO in breast cancer

吲哚胺2，3双加氧酶（IDO）是重要的免疫抑制分子，在移植免疫耐受和肿瘤的免疫抑制方面均具有重要作用。近年来研究表明，IDO在乳腺癌中高表达，IDO可通过抑制NK细胞和效应T细胞促进调节性T细胞（Treg）浸润、诱导乳腺癌新生血管的生成等机制，使癌细胞易于逃避免疫监视并加速肿瘤的生长和转移，推动乳腺癌病程的进展。因此，IDO参与乳腺癌免疫耐受相关机制方面的研究，对乳腺癌的靶向治疗策略具有重要意义。

As an important immunosuppressive molecule, indole-amine 2,3-dioxygenase （IDO） plays an important role in immune tolerance during transplantation and tumor-induced immunosuppression. It has been shown that IDO is highly expressed in breast cancer. By inhibiting NK cells and effector T cells, IDO promotes the infiltration of regulatory T cells （Treg） and induces angiogenesis in breast cancer, which makes it possible for cancer cells to evade immune surveillance, accelerate tumor growth and metastasis promoting the progress of the course of breast cancer. Therefore the study on specific mechanism that IDO was involved in immunologieal tolerance of breast cancer has the important significance for therapeutic strategy of breast cancer.