长链非编码RNA及其与病毒关系的研究进展

Research progress in long noncoding RNA and its relationship with virus

主要针对长链非编码RNA及其与病毒的关系,尤其是长链非编码RNA在病毒致病中的功能进行了综述.长链非编码RNA(long noncoding RNA,lnc RNA)是一类广泛存在于生物体内、转录本长度超过200个核苷酸单位的非编码RNA分子,主要在表观遗传学、转录及转录后等水平上调控基因的表达.lnc RNA已经被证实在多种生命现象中发挥着重要作用,包括影响细胞生长、增殖、凋亡及肿瘤发生.病毒感染普遍会引起宿主lnc RNA的表达发生改变,且病毒自身编码的lnc RNA同样能够调控宿主细胞基因的表达,以利于病毒的复制与感染.对于lnc RNA与病毒感染关系的深入研究,必将对认识病毒-宿主相互作用及相关疾病的治疗带来新的启示.

It was summarized the recent progress in long noncoding RNA and its relationship with virus,especially the function of long noncoding RNA on virus-induced oncogenesis. Long noncoding RNA（ lnc RNA） was a noncoding RNA longer than 200 nucleotides,which could regulate gene expression at epigenetic,transcription and post-transcription level,and widely existed in the organism. It had been demonstrated that lnc RNA play an important role in many life phenomena,which include cell proliferation,apoptosis and tumorigenesis.The role of lnc RNA in the process of viral infection and carcinogenesis was summarized. The infection of virus generally would change the expression of the hosts＇ lnc RNA. The lnc RNA encoded by virus could also modulate the expression of the hosts＇ gene which was critical for the infection of virus. Efforts on the researches of long noncoding RNA and its relationship with virus might give new insights into virus-host interactions and therapy of related diseases.