中医辨证论治与红霉素疗法治疗支气管扩张症稳定期的对比研究

Comparative Study on Effects of Syndrome Differentiation and Treatment of Traditional Chinese Medicine and Erythromycin Therapy for the Treatment of Bronchiectasis of Stable Period

目的:观察中医辨证论治与长期小剂量红霉素疗法在成人支气管扩张症稳定期中的疗效对比。方法:以中药辨证治疗组和西药对照组进行随机、单盲、平行对照研究,选取符合诊断标准和纳入标准的门诊患者共102例,观察随机单盲对照试验的疗效,采用呼吸困难评分(MMRC)、圣乔治呼吸问卷(SGRQ)、急性加重次数、肺功能、胸部HRCT影像学评分作为疗效评价标准进行疗效评价。结果:2组共脱落4例患者,经治疗后,治疗组呼吸困难评分、急性发作频率低于对照组(P<0.05);治疗组圣乔治总评分明显降低(P<0.05)。结论:以健脾益气、化痰解毒为主的中药辨证治疗组,能改善支气管扩张稳定期患者的临床症状,提高患者生活质量,减少急性发作次数,值得进一步研究及推广。

Objective： To evaluate the effects between Chinese medical syndrome differentiation and treatment and low-dose erythromycin for the treatment of bronchiectasis of stable period. Methods： A total of 102 patients with stable bronchiectasis were randomly divided into control group and TCM group. Efficacy measures were dyspnea scores（ MMRC）,scores of St Georges respiratory questionnaire（ SGRQ）,the frequency of acute exacerbations,pulmonary function test and HRCT. Results： After the six months of treatment,four cases in the TCM group and the control group dropped out. The score of dyspnea and the frequency of acute exacerbations of the TCM group decreased significantly than the control group（ P〈0. 05）. And the scores of St Georges respiratory questionnaire of the TCM group decreased significantly（ P〈0. 05）. Conclusion： The TCM group which mainly based on Chinese drugs for benefiting-qi,activating-blood may improve conditions of patients with bronchiectasis,enhance the quality of life and reduce the frequency of acute exacerbations. Therefore,it is worthy of further study.