抑郁症与炎症

Depression and Inf lammation

抑郁症(depression)是一种以情绪低落、悲观厌世、认知和睡眠障碍为主要特征的情感性精神障碍,临床一线抗抑郁药主要是基于单胺假说的药物,通过对单胺递质的调节发挥抗抑郁作用,尽管疗效肯定,但普遍存在起效延迟、有效率低、不良反应多等诸多缺憾,单胺假说也不能解释抑郁症的全部现象。因此,近年来除单胺假说外的其它假说越来越引起重视,炎症假说认为应激刺激引发炎症过程,最终导致抑郁症的发生,该文着重通过抑郁症的(神经)炎症假说阐述抑郁症与炎症的关系。

Depression is an affective disorder characterized by a state of low mood, pessimism, cognitive and sleep disorders. Despite the widespread prescription of monoaminergic neurotransmitter modulators, the monoamine hypothesis cannot explain all the phenomena of depression. Moreover, limited drug efficacies, slow onset of action and undesirable side effects have made urgent the task of discovering novel therapeutics. Thus, several hypotheses other than the monoamine hypothesis have received much attention in recent years. The inflammatory hypothesis of depression is that inflammatory mechanisms play a crucial role in the pathophysiological mechanisms of major depression. This review will focus on progress of the （neuro）inflammatory hypothesis of depression.