单唾液酸四己糖神经节苷脂对新生儿窒息并发缺血缺氧性脑病的疗效

Clinical Efficacy of Monosialoteterahexosyl Ganglioside in Treatment of Neonatal Asphyxia Complicated by Hypoxic-ischemic Encephalopathy

目的探讨单唾液酸四己糖神经节苷脂对新生儿窒息并发缺血缺氧性脑病(HIE)患儿的临床效果。方法选择2011年3月—2014年3月哈尔滨医科大学附属第一医院收治的新生儿窒息并发HIE患儿92例随机分为观察组(n=46)和对照组(n=46)。对照组采用常规对症治疗,观察组在对照组基础上予单唾液酸四己糖神经节苷脂治疗。两组疗程均为14 d。对比分析两组疗效、新生儿行为神经评分法(NBNA)评分、血清S100β和NSE水平、不良反应及后遗症发生率。结果 1观察组总有效率显著高于对照组(P<0.05);2两组治疗后14 d(治疗后)NBNA评分均较治疗前显著下降(P<0.05),治疗后观察组NBNA评分显著低于对照组(P<0.05);3两组治疗后血清S100β和NSE水平较治疗前显著降低(P<0.05),治疗后观察组血清S100β和NSE水平显著低于对照组(P<0.05);4治疗期间两组均未见严重不良反应发生;5两组治疗后随访12个月观察组后遗症发生率显著少于对照组(P<0.05)。结论单唾液酸四己糖神经节苷脂对新生儿窒息并发HIE疗效显著且安全性好。

Objective To investigate the clinical efficacy of Monosialoteterahexosyl Ganglioside in treatment of neo- natal asphyxia complicated by hypoxic-ischemic encephalopathy （HIE）. Methods A total of 92 patients with neonatal as- phyxia complicated by HIE diagnosed during March 2011 and March 2014 were randomly divided into observation group （n = 46） and control group （n = 46）. The control group was treated with conventionally symptomatic treatment, while the observa- tion group was treated with Monosialoteterahexosyl Ganglioside： The courses of treatment in the two groups were 14 d. The effi- cacy, neonatal behavioral neurological assessment （NBNA） score, the serum S100I~ and neuron -specific enolase （NSE） lev- els, incidence rates of adverse reaction and sequel in the two groups were compared and analyzed. Results The total effective rate in the observation group was significantly higher than that in the control group （P 〈 0. 05） ; the NBNA scores were signifi- cantly lower 14 d after the treatments than those before the treatment in the two groups （P 〈0. 05）, and after the treatment the NBNA score in the observation group was significantly lower than that in the control group （P 〈0. 05） ; after the treatment, the serum S100β and NSE levels in the two groups were significantly lower than those before the treatment （P 〈0. 05）, and the levels in the observation group were significantly lower than those in the control group （P 〈 0. 05） ; there was no serious ad- verse reaction during the treatment; the incidence rate of sequela in the observation groups was significantly lower than that in the control group with a 12-month follow-up （P 〈 0. 05）. Conclusion The Monosialoteterahexosyl Ganglioside in treatment of the neonatal asphyxia complicated by HIE has obvious efficacy and safety.