中药联合特异性免疫治疗小儿过敏性哮喘118例效果分析

Effect of Traditional Chinese Medicine Combined with Specific Immunotherapy in Treatment of Allergic Asthma in Children( an Analysis of 118 Cases)

目的观察中药联合特异性免疫治疗小儿过敏性哮喘的临床效果。方法选择北京航天总医院2010年2月—2013年11月收治的确诊为过敏性哮喘的患儿236例随机分成对照组和观察组,每组118例。对照组予标准化特异性免疫治疗,观察组在对照组基础上加服红参片及自拟去敏方剂治疗,疗程为12个月。观察比较两组疗效,治疗前及治疗后2、3、4、5、6、12个月的症状评分、呼气流量峰值(PEF)变化,治疗期间急性发作次数及不良反应发生率。结果观察组总有效率显著高于对照组(P<0.01)。与本组治疗前比较,观察组症状评分、PEF治疗后5个月开始显著下降(P<0.01),对照组直到治疗后6个月才开始显著下降(P<0.01);观察组治疗后5、6、12个月症状评分及PEF显著低于对照组(P<0.01)。观察组治疗期间急性发作次数与不良反应发生率均显著低于对照组(P<0.01)。结论采用中药联合特异性免疫治疗能改善过敏性哮喘患儿的免疫功能,减少复发,降低不良反应发生率,效果满意。

Objective To observe the clinical effect of traditional Chinese medicine combined with specific im- munotherapy in treatment of children with allergic asthma. Methods A total of 236 children diagnosed as having allergic asthma during February 2010 and November 2013 were randomly divided into control group （n = 118） and observation group （n = 118）. The control group was treated with standardized specific immunotherapy, while the observation group was treated with Red Ginseng slice and self-desensitization prescription treatment based on the standardized specific im- munotherapy, and the course of treatment was 12 months. The efficacy of the two groups was compared, and symptom scores and peak expiratory flow （PEF） changes before and in the 2nd, 3th, 4th, 5th, 6th and 12th months after the treat- ment, frequency of acute episode and incidence rate of adverse reaction during the treatment were also observed and com- pared in the two groups. Results The total effective rate of the observation group was significantly higher than that of the control group （P 〈 0. 01 ）. Compared with those before the treatment, the values of symptom score and PEF began to sig- nificantly decrease in the 5＇h month after the treatment in the observation group （P 〈 0. 01 ） , and the control group, while the values began to significantly decrease in the 6th month after the treatment （P 〈 0.01 ）. The values of symptom scores and PEF in the observation group in the 5＇h , 6th and 12th months after the treatment were significantly lower than those in the control group （P 〈 O. 01 ）. During the treatment, the values of frequency of acute episode and the incidence rate of adverse reactions in the observation group were significantly lower than those in the control group （P 〈0. 01 ）. Conclu- sion The traditional Chinese medicine combined with specific immunotherapy in treatment of children with allergic asth- ma can improve the immune function, reduce the recurrence rate and incidence rate of adverse reaction.