成组序贯Ⅰ类错误损耗函数期中分析方法

THE INTERIM ANALYSIS METHOD OF GROUP SEQUENTIAL DESIGN BASED ON THE TYPE ONE ERROR RATE SPENDING FUNCTION.

目的 :介绍 α损耗函数期中分析方法的基本原理。方法 :结合实例说明期中分析方法的应用 ,以及最大样本数及信息部分的计算。结果 :该法既可控制重复显著性检验的 类错误率 ,又无需事先指定期中分析次数和时间。结论 :该法具有很大的灵活性 ,信息部分将期中分析和第 类错误损耗函数建立联系 。

Objective:To introduce the principle of α spending function method.Method:To describe its use and the calculation of the maximum sample size and information fraction.Result:This method can control the type one error probability for repeated significance tests while the frequency and time of analysis need not be prespecified.Conclusion:This method has great flexibility in use,information fraction is crucial for interim analysis,which relates interim analysis to α spending function.