联合用药对儿童厌食症疗效及对食欲调节因子的影响

Curative effect of combined therapy on child anorexia and the influence on appetite regulation factors

目的：探讨双歧杆菌三联活菌散联合四磨汤治疗儿童厌食症患者疗效及对食欲调节因子的影响。方法选择收治儿童厌食症患者78例，随机分为联合组（ n＝39例）和对照组（ n＝39例）。两组患儿均予以调整饮食及纠正不良饮食习惯等基础治疗。联合组患儿加用双歧杆菌三联活菌散（双歧杆菌三联活菌散1．0g／次，3次／d，温开水冲服）联合四磨汤（10mL／次，3次／d，温服）治疗，对照组患儿单纯加用四磨汤（10mL／次，3次／d，温服）治疗，疗程均为8周。检测并比较两组患儿治疗前后血清胃动素（ MTL）和P物质（ SP）水平，并评估其临床疗效。结果治疗8周后，两组患儿血清MTL和SP水平较前明显上升（联合组t值分别为2．92、3．25，对照组t值分别为2．29、2．42，均P＜0．05），且联合组治疗后血清MTL和SP水平较对照组更高（t值分别2．33、2．41，P＜0．05）；同时临床总有效率方面联合组患儿（94．87％）优于对照组（79．49％），差异具有统计学意义（χ2＝4．13，P＜0．05）。结论双歧杆菌三联活菌散联合四磨汤治疗儿童厌食症患者疗效明显优于单用四磨汤治疗，能明显改善患儿的厌食症状，其机制可能与其能升高血清食欲调节因子MTL和SP水平，提高患儿食欲密切相关。

Objective To discuss the curative effect of live combined bifidobacterium, lactobacillus and enterococcus powder combining decoction of four-drug juice on anorexic children and its influence on appetite regulation factors.Methods Totally 78 cases of anorexic children were selected and randomly divided into combined group （ n=39 ） and control group （ n=39 ） .Two groups were given basic medical treatment, such as diet adjustment, correction of poor eating habits.The combined group was additionally given live combined bifidobacterium, lactobacillus and enterococcus powder （1.0g per time, three times a day with warm boiled water） combining with decoction of four-drug juice （10ml per time, three times a day with warm boiled water） for a course of 8 weeks, while the control group was provided with decoction of four-drug juice （10ml per time, three times a day with warm boiled water）.The serum MTL and SP levels of children in two groups were detected and compared before and after medical treatment, and the clinical curative effect was evaluated as well.Results After 8-week medical treatment, serum MTL and SP levels of children in two groups rose obviously than before （ tcombined group value was 2.92 and 3.25, respectively, tcontrol group value was 2.29 and 2.42, respectively, all P〈0.05）, and the levels in the combined group were much higher than those in the control group （t value was 2.33 and 2.41, respectively, both P〈0.05）.Meanwhile, total clinical efficiency of children in the combined group （94.87%） was significantly higher than that in the control group （79.49%） （χ2 =4.13,P〈0.05） .Conclusion Compared with decoction of four-drug juice, live combined bifidobacterium, lactobacillus and enterococcus powder combining decoction of four-drug juice has more favorable curative effect on anorexic children, which can obviously improve anorexic symptom, and the possible mechanism might be raising serum appetite regulation factors MTL and SP levels to enhance appetite of children.