HPV16在宫颈癌前病变及宫颈癌中的检测及临床意义

HPV16 testing and its clinical significance in precancerous lesions and cervical cancer

目的：探究与分析人乳头瘤病毒16（HPV16）在宫颈癌前病变及宫颈癌中的检测及临床意义。方法选取新疆维吾尔自治区人民医院米东医院妇产科自2012年12月至2014年12月收治的宫颈癌前病变与宫颈癌患者95例，其中宫颈癌前病变60例，宫颈癌35例，分别作为癌前病变组与宫颈癌组，全部患者均经过严格操作后对其中HPV16进行检测。结果在宫颈癌前病变中，宫颈上皮内瘤变（CIN）Ⅱ级的阳性率明显高于CINⅠ级（χ^2＝4．56，P＜0．05），CINⅢ级的阳性率明显高于CINⅡ级（χ^2＝5．24，P＜0．05），宫颈癌组的阳性率明显高于宫颈癌前病变组（χ^2＝6．88，P＜0．05）。 CINⅡ级的HPV16水平明显高于CINⅠ级（t＝3．89，P＜0．05），CINⅢ级的HPV16水平明显高于CINⅡ级（t＝4．33，P＜0．05），宫颈癌组的HPV16水平明显高于宫颈癌前病变组（t＝5．21，P＜0．05）。结论 HPV16感染是诱发宫颈癌前病变与宫颈癌的重要因素，对患者进行早期HPV16检测可有利于疾病的治疗与预防，有重要临床应用价值。

Objective To explore and analyze HPV16 testing and clinical significance in precancerous lesions and cervical cancer. Methods From December 2012 to December 2014 totally 95 cases of precancerous lesions and cervical cancer admitted in People ’ s Hospital of Meters East Hospital in Xinjiang Uygur Autonomous Region were selected, including 60 cases of precancerous lesions in precancerous lesion group and 35 cases of cervical cancer in cervical cancer group.After rigorous operation all cases received HPV16 testing.Results In precancerous lesions, the positive rate was significantly higher in CINⅡ than in CIN Ⅰ （χ2 =4.56,P〈0.05）, and that was significantly higher in CINⅢthan in CINⅡ（χ2 =5.24,P〈0.05）.Compared with precancerous lesion group, the positive rate was significantly higher in cervical cancer group （χ2 =6.88, P〈0.05）.HPV16 level in CINⅡ was significantly higher than in CIN Ⅰ（t=3.89,P〈0.05）, and that in CIN Ⅲ was higher than in CINⅡ（t=4.33,P〈0.05）.HPV16 level in cervical cancer group was remarkably higher than that in precancerous lesion group （t =5.21,P 〈0.05）.Conclusion HPV16 infection is an important factor inducing precancerous lesions and cervical cancer.Early HPV16 testing is beneficial to the treatment and prevention of disease, and it had essential clinical value.