摘要
目的：探讨黛力新联合氟桂利嗪治疗更年期女性偏头痛的疗效及对脑血流动力学的影响。方法选择120例更年期女性偏头痛患者随机分为观察组和对照组各60例，观察组给予黛力新联合氟桂利嗪进行治疗，对照组单纯给予氟桂利嗪治疗，连续治疗3个月后，比较两组患者治疗前后头痛发作频率、脑血流动力学改善情况及疗效。结果观察组治疗后头痛发作频率、头痛的疼痛视觉模拟评分法（VAS）评分均较对照组明显更低，经比较差异均有统计学意义（t发作频率＝15．095、tVAS评分＝14．114，均P＜0．05）；观察组有效率为98．33％，高于对照组的88．33％，经比较差异有统计学意义（χ2＝26．227，P＜0．05）；观察组治疗后大脑中动脉（MCA）、大脑前动脉（ACA）、大脑后动脉（PCA）、椎动脉（VERT）、基底动脉（BSLR）血流速度均较对照组明显更低，经比较差异均有统计学意义（tMCA ＝12．315、tACA ＝14．001、tPCA ＝11．082、tVERT ＝13．069、tBSLR ＝12．886，均P＜0．05）。结论黛力新联合氟桂利嗪治疗更年期女性偏头痛疗效较好，脑血流动力学指标改善明显。
Objective To explore the therapeutic effect of deanxit combined with flunarizine for menopausal women with migraine and its influence on cerebral hemodynamics indicators.Methods Totally 120 menopausal women with migraine were randomly divided into observation group and control group with 60 cases in each.The observation group was treated with deanxit combined with flunarizine, while the control group was treated with flunarizine only.After 3 months of continuous treatment, headache frequency and improvement of cerebral hemodynamics before and after treatment were compared between two groups.Results The headache frequency and headache VAS score of the observation group were significantly lower than those of the control group, and the differences were statistically significant （ t value was 15.095 and 14.114,respectively, both P〈0.05）.The effective rate of the observation group （98.33%） was higher than that of the control group （88.33%） with significant difference （χ2 =26.227,P〈0.05）.After treatment, blood flow velocity of MCA, ACA, PCA, VERT and BSLR in the observation group were significantly lower than those in the control group, and the differences were significant （t value was 12.315, 14.001, 11.082, 13.069 and 12.886, respectively, all P〈0.05）.Conclusion Deanxit combined with flunarizine in the treatment of migraine in menopausal women has significant effect and can significantly improve cerebral hemodynamics indicators.
出处
《中国妇幼健康研究》
2015年第5期1024-1026,共3页
Chinese Journal of Woman and Child Health Research
