前列地尔治疗高龄糖尿病并慢性肾脏病患者疗效分析

Alprostadil in the Treatment of Elderly Diabetic Patients with Chronic Kidney Disease and Curative Effect Analysis

目的分析前列地尔治疗高龄糖尿病并慢性肾脏病患者疗效。方法回顾性分析该院2014年6月—2015年6月收治的128例高龄糖尿病并慢性肾脏病患者临床资料,根据不同治疗方案分为两组,对照组(70例)予以常规治疗,研究组(58例)于对照组基础上予以前列地尔治疗,观察并比较两组临床疗效、治疗前后的肾功能指标变化及不良反应情况。结果研究组治疗总有效率94.83%比对照组70.00%高,且Cr、24h UAER、Cys C及Ccr指标改善幅度显著大于对照组,均差异有统计学意义(P<0.05);研究组不良反应总发生率25.86%比对照组18.57%略高,差异无统计学意义(P>0.05)。结论前列地尔治疗高龄糖尿病并慢性肾脏病患者疗效显著,可有效改善患者临床症状,降低蛋白尿,且安全性高,值得临床推广及应用。

Objective To analyze the front to the treatment of elderly patients with diabetes and chronic kidney disease（CKD）. Methods A retrospective analysis in June 2014- June 2015 treated 128 cases of elderly patients with diabetes and chronic kidney disease（CKD） clinical data, according to the different treatments are divided into two groups, control group（70 cases） to conventional treatment, research group（58 cases） in the control group based on to the front to treatment, to observe and compare the two groups of clinical curative effect, changes of renal function indexes before and after treatment,and adverse reactions. Results Treatment group total effective rate was 94.83% higher than the control group 70.00%, 24 huaer, Cys C and Cr, and Ccr index improvement was significantly greater than the control group, were statistically significant（P0.05）; Team of adverse reactions to the total incidence of 25.86% than the control group 18.57% slightly tall, not shown height difference（P0.05）. Conclusion Front row, diabetes and chronic kidney disease（CKD） in aged patients with obvious therapeutic effect, can effectively improve the patients＇ clinical symptoms, reduce proteinuria, and high safety, worthy of clinical popularization and application.