炎性细胞因子在蒸发过强型干眼的发病机制中的作用

Role of inflammatory cytokines in the pathogenesis of evaporative dry eye

目的:探讨炎性细胞因子在蒸发过强型干眼的发病机制中的作用。方法:选择2010-01/2015-01我院诊治的蒸发过强型干眼患者39例65眼为研究对象。另取健康体检者30例53眼为对照组,对所有患者进行抗炎药物治疗。治疗前测定两组泪液TNF-α、IL-1、IL-6、IL-8水平进行组间比较,并于治疗后1、4、10wk检测试验组上述各炎性因子水平进行组内比较。结果:对照组的泪液TNF-α、IL-1、IL-6、IL-8水平均显著低于试验组,差异具有统计学意义(P<0.05)。治疗后1、4、10wk时观察指标评价结果存在统计学意义(P<0.05),提示随着治疗时间的延长,患者各项观察指标均逐渐朝向正常值方向变化。治疗后1、4、10wk患者泪液TNF-α、IL-1、IL-6、IL-8比较存在统计学差异,上述各项指标均呈逐渐下降趋势,具有统计学差异(P<0.05)。结论:TNF-α、IL-1、IL-6、IL-8在蒸发过强型干眼症患者中特异性升高,可作与疾病的发生发展密切相关,可作为临床诊断或疗效监测的重要参考指标。

AIM：To study the role of inflammatory cytokines in the pathogenesis of evaporative dry eye.METHODS：Thirty-nine patients（65 eyes） with evaporative dry eye treated from January 2010 to January2015 in our hospital were selected as test group.Thirty healthy check-ups（53 eyes） were selected as control group.All the patients took the anti-inflammatory drugs.Before treatments,the levels of TNF-α,IL-1,IL-6,IL-8 of two groups was compared.After 1,4 and10 w of treatments,the levels of inflammatory cytokines of two groups was compared.RESULTS：The levels of TNF-a,IL-1,IL-6,IL-8 of control group were significantly lower than those of test group（P〈0.05）.After 1,4 and 10 wk of treatments,the observed indexes of two groups were significantly different（P 0.05）.With the extension of treatment time,the indexes gradually returned to normal;at 1,4and 10 wk after treatments,the levels of TNF-a,IL-1,IL-6,IL-8 of two groups were significantly different.The mentioned indexes were gradually reduced（P〈0.05）.CONCLUSION：For patients with evaporative dry eye,TNF-α,IL-1,IL-6 and IL-8 increase specifically,which are closely correlated with the occur and progress of this disease,regarded as the important reference indexes for clinical diagnosis and efficacy monitoring.