深圳市霍乱散发的病原学特征分析

PATHOGENICITY CHARACTERS OF SPORADIC OUTBREAK OF VIBRIO CHOLERA IN SHENZHEN CITY.

目的 :探讨深圳市霍乱散发的病原学特征。方法 :采用血清学和分子生物学相结合的方法 ,研究深圳地区散发不同血清型霍乱弧菌的生化特性、质粒、肠毒素基因携带和耐药状况。结果 :散发性霍乱以无毒株为主 ,质粒及肠毒素基因的携带率极低 ,但耐药性有所增加。结论 :本地区霍乱散发呈现非典型性 ,致病力弱 。

Objective:To study the pathogenicity characters of Vibrio cholera in Shenzhen city.Methods:With serological and molecular techniques,we study chemical property,plasmid,CT gene and drug resistance of sporadic outbreak of vibro cholera in Shenzhen city.Results:The sporadic outbreak of vibrio cholera has some characters:including non toxic strain infection,low detection rate of plasmid and CT gene and increase of drug resistance.Conclusion:The pathogenic characters of sporadic vibrio cholera outbreak lack characters of toxic vibrio cholera.Its pathogenicity capacity is low.The mutagenesis of heredity and increase of drug resistance make it difficult the prevention and therapy of vibrio cholerae.