高磷血症与终末期肾病的研究进展

Research Progress of Hyperphosphatemia in End-stage Renal Disease

高磷血症是终末期肾病(ESRD)中很常见的一种电解质紊乱,常出现甲状旁腺功能亢进、肾性骨病及心血管钙化等并发症,是影响ESRD患者预后和生活质量的重要因素。ESRD中高磷血症发生机制、临床危害及治疗正逐渐得到人们的重视。目前高磷血症的治疗仍以血液透析及磷结合剂的应用为主,近年来一些新型药物的出现使治疗的不良反应更少,获益更多。

Hyperphosphatemia is a very common electrolyte disorder in end-stage renal disease （ESRD） , and often induces many complications such as hyperparathyroidism, renal osteodystrophy, and cardiovascular calcification. It is an important factor which can affect prognosis and quality of life of ESRD patients. The mechanism, clinical harm and treatment are gradually getting people＇s attention. At present, the treatment of hyperphosphatemia is still mainly by hemodialysis and phosphate binders. In recent years some new drugs are emerging with fewer side effects and more benefit.