期刊文献+
任意字段
题名或关键词
题名
关键词
文摘
作者
第一作者
机构
刊名
分类号
参考文献
作者简介
基金资助
栏目信息

PI3K/AKT/mTOR信号通路在卵巢癌中的研究进展 被引量：8

Research Progress of PI3K/AKT/mTOR Pathway in Ovarian Cancer
下载PDF
导出
摘要 卵巢癌的发生过程中存在磷脂酰肌醇3-激酶/蛋白激酶B/哺乳动物雷帕霉素靶蛋白(PI3K/AKT/m TOR)信号通路的激活,该通路的异常激活可促进细胞增殖、抑制细胞凋亡、促进肿瘤侵袭和转移。PI3K/AKT/m TOR通路靶向抑制剂对卵巢癌显示出一定的疗效,目前该靶向药物的临床试验已开展,并显示出良好的安全性和有效性。针对PI3K/AKT/m TOR的靶向药物将为卵巢癌的治疗指明新方向。 phosphoinositide-3 kinase/protein kinase B/mammalian target of rapamycin （PI3K/AKT/ mTOR） pathway activation exists in the process of ovarian cancer,and the abnormal activation leads to apoptosis inhibition, tumor cell proliferation promotion, tumor invasion and metastasis. PI3 K/AKT/mTOR inhibitors show curative effect on ovarian cancer and the clinical trials have been conducted, as the results showed satisfactory safety and effect. The drugs targeted at PBK/AKT/mTOR have pointed out a new way for ovarian cancer treatment.
作者 吴梦 王芳
机构地区 南京医科大学第一附属医院医学检验科
出处 《医学综述》 2015年第22期4085-4087,共3页 Medical Recapitulate
基金 国家自然科学基金(30901344 81272324) 江苏省医学重点学科(实验室)基金(XK201114)
关键词 卵巢癌 磷脂酰肌醇3激酶/蛋白激酶B/哺乳动物雷帕霉素靶蛋白信号通路 抑制剂 Ovarian cancer Phosphoinositide-3 kinase/protein kinase B/mammalian target of rapamycin pathway Inhibitors
分类号 R446.6 [医药卫生—诊断学]
  • 相关文献

参考文献31

  • 1Siegel R, Ma J, Zou Z, et al. Cancer statistics,2014 [ J ]. CA Cancer J Clin ,2014,64( 1 ) :9-29.
  • 2Altomare DA, Wang HQ, Skele KL, et al. AKT and mTOR phos- phorylation is frequently detected in ovarian cancer and can be tar- geted to disrupt ovarian tumor cell growth[ J]. Oncogene ,2004,23 (34) :5853-5857.
  • 3Isonishi S, Saitou M, Saitou M, et d. Differential regulation of the cytotoxlcity activity of paclitaxel by orobol and platelet derived growth factor in human ovarian carcinoma cells[ J]. Oneology Rep, 2007,18( 1 ) :195-201.
  • 4Yang X, Fraser M, Abedini MR, et al. Regulation of apoptosis- inducing factor-mediated, cisplatin-induced apoptosis by Akt [ J ]. Br J Cancer,2008,98 (4) : 803-808.
  • 5Shaw R J, Cantley LC. Ras, PI ( 3 ) K and mTOR signalling controls tumour cell growth[ J]. Nature ,2006,441 (7092) :424-430.
  • 6Katso R, Okkenhang K, Ahmadi K, et al. Cellular function of phos- phoinositide 3-kinases : implications for development, homeostasis, and cancer[J]. Annu Rev Cell Dev Biol,2001,17 :615-675.
  • 7Montero JC, Chen X, Ocafia A, et al. Predominance of mTORC1 over mTORC2 in the regulation of proliferation of ovarian cancer cells : therapeutic implications [ J ]. Mol Cancer Ther,2012,11 ( 6 ) : 1342-1352.
  • 8Peterson TR, Laplante M ,Thoreen CC ,et al. DEPTOR is an roTOR inhibitor frequently overexpressed in multiple myeloma cells and required for their survival[ J ]. Ce11,2009,137 (5) :873-886.
  • 9Sarbassov DD, Guertin DA, All SM ,et al. Phosphorylation and reg- ulation of Akt/PKB by the rictor-mTOR complex [ J ]. Science, 2005,307 (5712) :1098-1101.
  • 10Kinross KM, Montgomery KG, Kleinschmidt M, et al. An activating Pik3ca mutation coupled with Pten loss is sufficient to initiate ovar- ian tumorigenesis in mice [ J]. J Clin Invest, 2012, 122 (2) :553-557.

共引文献5

同被引文献105

  • 1钦可为,韩超峰,Cheng J,Quintin RA,Cramer KM.有氧糖酵解是受训免疫的代谢基础[J].中国肿瘤生物治疗杂志,2015,22(2):176-176. 被引量：1
  • 2郭澄,王雅君,张剑萍.菟丝子的化学成分和药理活性研究[J].时珍国医国药,2005,16(10):1035-1036. 被引量：80
  • 3蒋瑶祁,彭辉灿.VEGF家族及其受体与视网膜新生血管形成[J].国际眼科杂志,2006,6(5):1113-1116. 被引量：17
  • 4叶兰,徐晓玉,李荣亨,何正光,陈刚.三棱、莪术含药血清对培养的人脐静脉血管内皮细胞生长和VEGF表达的影响[J].第三军医大学学报,2007,29(2):121-124. 被引量：37
  • 5Renner C.Carnosine inhibits ATP production in cells from malignant glioma[J].Neurological Research,2010,32(1):101-105.
  • 6Haddad F,Ashley E;Michelakis ED.New insights for the diagnosis and management of right ventricular failure,from molecular imaging to targeted right ventricular therapy[J].Current opinion in cardiology,2010,25(2):131-140.
  • 7Rong,Cui,:Xing-Yao,Shi.Expression of pyruvate kinase M2in human colorectal cancer and its prognostic value[J].International journal of clinical and experimental pathology,2015,8(9):11393-9.
  • 8David Christensen,Philip C Calder,Franchesca D Houghton.GLUT3 and PKM2 regulate OCT4 expression and support the hypoxic culture of human embryonic stem cells[J].Scientific reports,2015,(5):17500.
  • 9Guanzhen Yu,Wenlong Yu,Guangzhi Jin,et al.PKM2regulates neural invasion of and predicts poor prognosis for human hilar cholangiocarcinoma[J].Molecular cancer,2015,14(1):193.
  • 10Niki Karachaliou,Jordi Codony-Servat,Cristina Teixidó,et al.BIM and mTOR expression levels predict outcome to erlotinib in EGFR-mutant non-small-cell lung cancer[J].Scientific reports,2015,5:17499.

引证文献8

二级引证文献24

医学综述
2015年 第22期

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部