阿奇霉素联合红霉素治疗小儿支原体肺炎临床分析

Azithromycin and Erythromycin in Treatment of Mycoplasma Pneumonia in Children

目的探讨阿奇霉素联合红霉素治疗小儿支原体肺炎的疗效。方法选择2012年5月至2013年2月上海市浦东新区浦南医院收治的小儿支原体肺炎患儿180例为研究对象,按照奇偶数法分为红霉素联合阿奇霉素组和阿奇霉素组,每组90例,分别给予患儿红霉素+阿奇霉素以及阿奇霉素治疗,3个疗程结束后比较两组患儿的疗效、退热时间、止咳时间以及住院时间。结果红霉素联合阿奇霉素组患儿的有效率为97.8%(88/90),显著高于阿奇霉素组的80.0%(72/90)(P<0.05)。红霉素联合阿奇霉素组患儿的退热时间、止咳时间以及住院时间均显著短于阿奇霉素组[(2.2±0.8)d比(3.8±1.2)d,t=2.349,P=0.009;(4.4±1.2)d比(6.4±1.5)d,t=2.064,P=0.011;(6.4±1.9)d比(8.0±3.3)d,t=2.620,P=0.005]。结论红霉素联合阿奇霉素治疗小儿支原体肺炎能快速缓解患儿的临床症状,其治疗效果显著优于阿奇霉素单一治疗。

Objective To explore the therapeutic effects of azithromycin and erythromycin in treatment of infantile mycoplasma pneumonia cases. Methods Total of 180 patients were selected from Punan Hospital of Pudong New Area from May 2012 to Feb. 2013 and divided into erythrocin group and erythrocin ＋ azithromycin group according to odevity. Erythrocin group was given erythrocin and erythrocin ＋ azithromycin group was given erythrocin and azithromycin, and the curative effect, antifebrile time, cough time, length of stay of the two groups were compared after three courses of treatment. Results The effective rate of erythro- cin ＋ azithromycin group after treatment was 97.8 % （88/90）, which was significantly higher than the eryth- rocin group [ 80. 0% （72/90） ] （ P 〈 0. 05 ）. The antifebrile time, cough time and the length of time stay of erythrmnycin ＋ azithromycin group were significantly shorter than those in azithromycin group [ （2.2 ± 0. 8 ） d vs （3.8±1.2） d,t=2.349,P=0.009;（4.4±l.2） des （6.4 ±1.5） d,t=2.064,P=0.011;（6.4±1.9 ） d vs （8.0 ±3.3 ） d, t = 2. 620, P = 0. 005 ]. Conclusion Erythromycin combined with azithromycin in treatment of children mycoplasma pneumonia can improve the clinical symptoms quickly, and the treatment effectiveness is superior than azithromycin single treatment.