华南汉族成人烟雾病的危险因素分析

Risk factors of Moyamoya disease in Han adults of southern China

目的:探讨华南汉族成人烟雾病的危险因素。方法:从本院2005年1月-2014年6月收治的烟雾病患者中选取300例为烟雾病组,另选取同期在本院行体检健康人员300例为健康组,对两组观察对象既往病史及实验室检查结果进行回顾性分析,同时对烟雾病相关危险因素进行筛选。结果:两组观察对象既往病史显示,烟雾病组具有糖尿病史、高血压病史、高血脂病史及烟酒史患者明显多于健康组(P<0.05)。两组观察对象实验室检查结果显示,烟雾病组患者血压、血糖、低密度脂蛋白胆固醇明显高于健康组(P<0.05),红细胞及白细胞无明显差异(P>0.05),回归分析结果显示:血压因素、糖尿病因素、血脂异常因素、肥胖因素、嗜酒因素、嗜烟因素、精神因素以及长期缺乏运动因素都是烟雾病的主要危险因素(P<0.05)。结论:华南汉族成人烟雾病的危险因素包括:血压因素、糖尿病因素、血脂异常因素、肥胖因素、嗜酒因素、嗜烟因素、精神因素以及长期缺乏运动因素,临床需进行针对性防治,减少发病率,提高治疗效果。

Objective： To investigate the risk factors of Moyamoya disease in Han adults of southern China.Methods： A total of 300 patients with Moyamoya disease admitted to our hospital between January 2005 and June2014 was recruited as the affected group. A contemporary cohort of 300 individuals who underwent health checkup at our hospital was recruited as the healthy group. The two groups were reviewed for medical history and laboratory findings. Meanwhile,risk factors of Moyamoya disease were screened. Results： Compared with those in the healthy group,there were more patients with history of diabetes,hypertension,hyperlipidemia,alcohol use or smoking in the Moyamoya group（ P〈0. 05）. Analysis of laboratory findings showed that the blood pressure and levels of blood glucose and low density lipoprotein cholesterol were significantly higher in the Moyamoya group than those in the healthy group（ P〈0. 05）. No significant differences in red blood cells and white cells were found between the two groups（ P〈0. 05）. Regression analysis showed that diabetes,hypertension,dyslipidemia,smoking and drinking,long-term mental stress,lack of exercise and obesity were risk factors for Moyamoya disease（ P〈0. 05）. Conclusion： Risk factors for Moyamoya disease in Han adults of southern China may include diabetes,hypertension,dyslipidemia,obesity,smoking and drinking,long-term mental stress,and lack of exercise. Clinical efforts should be exerted to targeted prevention and control,reduce morbidity,and improve the treatment efficacy.