原发性高血压患者中心动脉压与尿微量白蛋白的相关性研究

Correlation between central aortic pressure and urine microalbumin in patients with essential hypertension

目的：探讨原发性高血压患者中心动脉压与尿微量白蛋白（m ALB）的关系。方法：选择2012年10月至2014年9月在本科住院并行冠脉造影者100例作为研究对象,根据u-m ALB分为微量白蛋白尿组（u-m ALB 30~300 mg/24 h）和对照组（u-m ALB〈30 mg/24 h）。比较两组中心动脉收缩压、舒张压及脉压的差异,Logistic多因素回归分析m ALB、年龄、性别、吸烟、高脂血症与中心动脉压的相关性。结果：微量白蛋白尿组中心动脉收缩压、舒张压及脉压均高于对照组（P〈0.05）。m ALB与中心动脉压正相关（r=0.322,P〈0.01）;年龄（r=0.124）、性别（r=0.126）、吸烟（r=0.109）、高脂血症（r=0.131）与中心动脉压无相关性（P〉0.05）。结论：原发性高血压患者中心动脉压与m ALB密切相关。

Objective： To investigate the correlation between central aortic pressure and urine microalbumin（ m ALB） in patients with essential hypertension（ EH）. Methods： A total of 100 EH patients,who were hospitalized and underwent coronary angiography in our hospital between October 2012 and September 2014,were included as the subjects in the study. All patients were divided into the urine m ALB group（ u-m ALB 30- 300 mg /24h） and the control group（ u-m ALB 30 mg /24h） according to u-m ALB. The differences in the systolic pressure,diastolic pressure,and pulse pressure of the central artery between the two groups were compared. The correlation between m ALB,age,sex,smoking status,hyperlipemia and central aortic pressure was analyzed by Logistic multivariate regression analysis. Results： The systolic pressure,diastolic pressure,and pulse pressure of the central artery in the u-m ALB group were all higher than those in the control group（ P〈0. 05）. Significant correlation was found between m ALB and central aortic pressure（ r = 0. 322,P〈0. 01）. No significant correlation was found between age（ r = 0. 124）,sex（ r = 0. 126）,smoking status（ r = 0. 109）,hyperlipemia（ r= 0. 131） and central aortic pressure（ P〈0. 05）. Conclusion： Central aortic pressure is significantly correlated with m ALB in EH patients.