帕金森病患者非运动症状发生及相关影响因素的研究

Clinical study on prevalence of non-motor symptoms in Parkinson disease and its influencing factors

目的研究帕金森病(PD)非运动症状的发生和分布情况及其与多种相关因素的关系。方法对68例原发性PD患者使用统一PD评分量表(u PDRs)、PD非运动症状30问卷量表(the PD NMS questionnaire,NMSQuest)、日常生活能力量表(ADL)和简易智能量表(MMs E)进行评分,并对非运动症状进行评估。结果所有PD患者各个时期病程均有非运动症状的出现,平均每个PD患者出现9项左右不同的非运动症状,并且非运动症状的发生与PD疾病的进展相关,与Hoehn and yahr(H-Y)分级呈正相关(P<0.01),与UPDRsⅢ运动评分呈正相关(P<0.01),且影响患者的生活质量,与ADL评分呈负相关P<0.05),而与年龄、性别、PD发病类型和左旋多巴每日治疗量无关(P>0.05)。结论非运动症状的发生在PD中很普遍,各项发生率随PD患者的临床特点及病程进展的情况变化,NMS发生数与PD的疾病严重程度呈正相关,对患者生活质量产生严重影响,需要全面认识和及时干预。

Objective To investigate the prevalence,distribution and its influencing factors of non-motor symptoms in Parkinson disease. Methods 68 patients with PD were analyzed use Unified Parkinson Disease Rating Scale（ UPDRS）,PDNMS Questionnaire,activities of daily living（ ADI）,and mini-mental state examination（ MMSE）to assess non-motor symptoms in patients with Parkinson disease. Results All the patients at different stage of PD,had 9 items of NMS on average. Total NMS score has a significant association with disease severity and progression,positively associated with H-Y stage（ P〈0. 01） and UPDRS IIIscore（ P〈0. 01）,negatively associated with ADL score（ P〈0. 05）. Age,sex distribution,daily dose of L-dopa and subtype of PD are irrelevant facts（ P〉0. 05）.Conclusions NMS are very common in PD patients,varies according to clinical future and course of disease. NMS affect patients＇ quality of life,and should be well recognized and treated.