淋巴细胞计数预测HIV/AIDS患者的CD4^+细胞数

Prediction of CD4^+ cell count by lymphocyte count in HIV/AIDS patients

目的研究HIV/AIDS患者外周血血常规检测指标与CD4+、CD8+淋巴细胞的相关性,寻求简易、廉价、高效、稳定的艾滋病病程的监测指标。方法采用回归分析等方法对282份HIV/AIDS患者血样白细胞(WBC)、淋巴细胞计数(W-SCC)、中性粒细胞计数(W-LCC)、红细胞(RBC)、血红蛋白浓度(HGB)、血小板(PLT)和CD4+、CD8+淋巴细胞数的相关性进行研究。结果 HIV/AIDS患者中血常规指标异常率较高,主要检测指标均在参考值范围内的仅占32.98%。HIV/AIDS患者血中WBC、W-SCC、W-LCC、RBC、HGB、PLT指标与CD4+淋巴细胞的相关关系均有统计学意义,相关系数分别为0.359、0.499、0.138、0.172、0.121、0.150。用W-SCC(x)估算CD4+淋巴细胞计数(y)的方程为y=101.32x+122.02。结论 HIV/AIDS患者淋巴细胞计数指标与CD4+淋巴细胞相关性较强,可以将其作为反映HIV/AIDS患者机体免疫状况及疾病发展阶段的一个重要指标。

Objective To study the correlations between routine blood test indexes and CD4^＋ , CD8^＋ cell count so as to look for a simple, inexpensive, efficient and stable indicator for AIDS progression monitoring. Methods Regreasion analysis were applied to study the correlations between WBC, W - SCC, W - LCC, RBC, HGB, PLT and CD4^＋, CD8^＋ cell count in 282 blood samples of HIV/AIDS patients. Results The abnormal rate of the routine blood test indexes among the HIV/AIDS pa- tients was high, and the main test indexes of only 32.98 % samples fell within the reference ranges. WBC, W - SCC, W - LCC, RBC, HGB and PLT were positively correlated with CD4^＋ cell count, and the correlation coefficients were 0. 359, 0. 499, 0. 138, 0. 172, 0. 121 and 0. 150 respectively. The equation between W- SCC （x） and CD4^＋ cell count （y） was as follow： y= 101.32x＋ 122.02. Conclusions The correlation between W - SCC and CD4^＋ cell count in the HIV/AIDS patients is strong. W- SCC can be considered as an important indicator of immune status and disease development stage in HIV/AIDS patients.