摘要
目的:探讨及分析治疗中枢性尿崩症药物的用药剂量及用药安全性的差异,为临床合理用药提供参考。方法:临床药师查阅近年来国内外文献,进行全面的综合、整理和归纳。结果与结论:治疗中枢性尿崩症以醋酸去氨加压素为主,治疗证据确切,为首选药物治疗。使用过程中需要根据尿量、尿渗透压、电解质、血压等指标,同时考虑使用人群对药物剂型、敏感性、吸收等存在的差异,并结合临床经验进行用药剂量的选择。
Objective:To investigate and analyze the differences in dosage and safety of drugs for the treatment of central diabetes insipidus to provide references for safe and rational drug use.Methods: Via searching for related literature published worldwide in recent years, a comprehensive integrated review was conducted.Results andconclusions: Desmopressin acetate is the ifrst-of-choice drug for the treatment of central diabetes insipidus with validated evidence. In the use of desmopressin acetate, the urine volume, urine osmotic pressure, electrolyte, blood pressure and other indicators should be taken into account, and the differences in sensitivity and absorption of pharmaceutical dosage forms should also be considered and combine with clinical experience for dose selection.
出处
《临床药物治疗杂志》
2015年第5期6-10,共5页
Clinical Medication Journal
关键词
中枢性尿崩症
药物
剂量
central diabetes insipidus
drug
dosage