丰城鸡血藤总黄酮抗血小板聚集及抗血栓作用研究

Studies on Antiplatelet Aggregation and Antithrombosis Action of Total Flavonoids of Millettia Nitida var. Hirsutissima Z.Wei

目的研究丰城鸡血藤总黄酮对实验性大鼠血小板聚集和血栓形成的影响。方法以二磷酸腺苷(adenosine diphosphate,ADP)、胶原和凝血酶作诱导剂诱导大鼠血小板聚集,丰城鸡血藤总黄酮按25,50,100 mg·kg?1的剂量灌胃给药,测定大鼠血小板聚集率,计算聚集抑制率;用血栓法测定大鼠血栓形成重量。结果丰城鸡血藤总黄酮各剂量均能抑制ADP、胶原和凝血酶诱导的大鼠血小板聚集,并能减少血栓形成的重量。结论丰城鸡血藤总黄酮具有明显的抗血小板聚集及抗血栓形成的作用。

OBJECTIVE To investigate the effects of total flavonoids of Millettia nitida var. Hirsutissima Z.Wei on platelet aggregation and thrombosis in experimental rats. METHODS The platelet aggregation of rats was induced by adenosine diphosphate（ADP）, collagen and thrombin. The rate of platelet aggregation was assayed by turbidity method, and the weight of thrombosis was determined by thrombus method in rats, which were administrated with 25, 50, 100 mg·kg？1 total flavonoids of Millettia nitida var. Hirsutissima Z.Wei. RESULTS Different doses of total flavonoids of Millettia nitida var. Hirsutissima Z.Wei could inhibit platelet aggregation induced by ADP, collagen and thrembin and reduce the weight of thrombosis in rats. CONCLUSION The total flavonoids of Millettia nitida var. Hirsutissima Z.Wei can remarkably inhibit platelet aggregation and thrombosis.