视网膜母细胞瘤局部浸润和远处转移的影像学表现

Imaging findings of retinoblastoma patients with direct extension and distant metastasis

目的探讨视网膜母细胞瘤(RB)局部浸润和远处转移的MRI和CT影像学表现特征。设计回顾性病例系列。研究对象14例伴有局部浸润和远处转移的RB患者。方法回顾性分析14例患者的MRI和CT影像学表现,包括直接浸润的方式、远处转移的部位、范围、信号和强化特征。主要指标MRI和CT表现。结果 14例患者中12例存在局部浸润,影像学表现为肿瘤沿视神经向后蔓延(11例),或侵犯眼周组织和邻近眶骨(1例)。14例患者中9例出现中枢神经系统转移病灶,3例发生骨转移,3例发生颈部淋巴结转移,2例于腮腺区见转移病灶,最常见的转移部位是中枢神经系统。结论 MRI或CT影像学检查可以及时发现RB远处转移的病变,为临床治疗提供依据。

Objective To study imaging findings for retinoblastoma patients with distant metastasis. Design Retrospective case series. Participants 14 retinoblastoma patients with distant metastasis. Methods The image of 14 retinoblastoma patients with distant metastasis were analyzed retrospectively. The magnetic resonance imaging（MRI） features analyzed included lesion location, morphology, scope and the characteristics of contrast. Main Outcome Measures MRI and computed tomography （CT） findings. Results 11 cases developed direct extension. Metastatic lesions were found in central nervous system in 9 patients, in bone in 3 patients, in neck lymph nodes in 3 patients. The central nervous system was the most common involved organ. Conclusion MRI and CT could find metastatic tumor of retinoblastoma, which were very useful for guiding clinical treatment.