儿童支原体肺炎免疫球蛋白、补体水平及动态变化

The changes of serum immunoglobulins and complements in children with mycoplasma pneumoniae pneumonia

目的比较肺炎支原体肺炎(MPP)、非MPP患儿和健康儿童的免疫球蛋白、补体水平,以探讨儿童MPP体液免疫指标的变化规律。方法分别检测52例MPP、55例非MPP患儿和33例健康儿童的血清免疫球蛋白(Ig G、Ig A、Ig M)、补体(C3、C4),并比较儿童MPP急性期和恢复早期体液免疫指标。结果 MPP组急性期血清Ig M、C3、C4水平高于非MPP组急性期和健康儿童(P<0.05)。儿童MPP恢复早期Ig M水平高于急性期,C4水平低于急性期(P<0.05)。结论与非MPP和健康儿童比较,MPP患儿存在明显体液免疫功能紊乱,从急性期到恢复早期,血清Ig M逐渐升高,补体C4先升高后降低,自身免疫反应可能参与了儿童MPP的发病过程。

Objective To investigate the changes of serum immunoglobulins and complement in children with mycoplasma pneumoniae pneumonia（ MPP）. Methods 52 children with MPP,55 children with non-MPP and 33 healthy children were enrolled. The levels of serum immunoglobulins（ Ig G,Ig A and Ig M） and complements（ C3,C4） were detected. Results Compared with the non-MPP group and healthy control,the levels of Ig M,C3 and C4 in MPP group during their acute phase were significantly higher（ P〈0. 05）. And among the MPP group the levels of Ig M were hisher and C4 were lower than that in the acute phase. Conclusion Immune function disturbance exists in children with MPP. From acute to recovery stage,the level of Ig M increased while C4 increased firstly and then decreased. Immune injury may be involved in the pathophysiology of childhood MPP.