植物乳杆菌发酵乳对高脂血症大鼠血脂的影响

Effect of Milk Product Fermented by Lactobacillus plantarum on Blood Lipids in Hyperlipidemia Rat

为了探讨植物乳杆菌发酵乳对实验性高脂血症大鼠血脂代谢的调节作用,为功能性发酵乳制品开发提供实验参考。采用高脂饲料喂养法,诱导形成大鼠高脂血症模型,将造模成功大鼠随机分为3组:高脂模型组、发酵乳样品组和自然降脂组。高脂模型组继续饲喂高脂饲料作为对照,发酵乳样品组饲喂高脂饲料的同时灌胃植物乳杆菌发酵乳,自然降脂组改为饲喂基础饲料,4周后测定各组大鼠的血脂浓度。结果显示,发酵乳样品组及自然降脂组与高脂模型组相比较,大鼠血清总胆固醇(TC)浓度显著下降(P<0.01),血清低密度脂蛋白胆固醇(LDL-C)浓度显著下降(P<0.01),血清高密度脂蛋白胆固醇(HDL-C)浓度升高(P<0.05),表明发酵乳样品对高脂血症大鼠血脂具有显著改善作用,通过调节饮食结构,高脂血症大鼠血脂可自行恢复正常。

The objective of this study was to investigate the effect of milk product fermented by Lactobacillus plantarum on blood lipids in hyperlipidemia rat and to provide experimental date for develeping functional fermented dairy product. The hyperlipidemia rat model was induced by high fat diet successfully and then the rats were randomly divided into 3 group：hyperlipidemia group, fermented milk group and the untreated group. The hyperlipidemia group were still fed high fat diet as control , the fermented milk group were fed not only high fat diet but also milk product fermented by Lactobacillus plantarum by gastric gavage and the untreated group changed to be fed basic diet. The blood lipids concentrations of each group were determined after a 4 weeks feeding period. The results showed that the concentrations of serum total cholesterol （TC） and low density lipoprotein-cholesterol （LDL-C） of the fermented milk group and the untreated group decreased significantly （P〈0.01）, also the concentrations of serum high density lipoprotein-cholesterol （HDL-C） of the fermented milk group and the untreated group increased significantly （P〈0.05） compared with hyperlipidemia group. The present results indicated that the milk product fermented by Lactobacillus plantarum could improve blood lipids in hyperlipidemia rat, and the blood lipids in hyperlipidemia rat can recover naturally by improving diet structure.