静息态脑功能网络分析方法及在肝性脑病的研究进展

Analyzing methods of resting-state brain functional network and the research progress in hepatic encephalopathy

静息态脑功能网络分析方法是目前脑功能研究最常用、最基本的方法之一。该方法利用血氧水平依赖功能磁共振成像(BOLD-f MRI)采集数据,分析全脑或特定脑区脑网络连接强弱的情况,不仅能无创定位功能网络连接异常的脑区,还能了解各种神经心理疾病的病理生理基础及发病机制。近年来,随着影像技术的发展、脑网络分析方法的不断完善,静息态脑功能网络的研究为临床疾病的诊断治疗提供了更为广阔的思路。

Resting-state brain functional connectivity is one of the most popular and basic methods for studing brain function at present. The method uses BOLD-fMRI to collect data and analyzes the functional networks of whole brain or specific regions. It can not only identify brain regions with abnormal functional connectivity noninvasively, but also can reveal pathophysiological mechanisms and the pathogenesis of many neuropsychological illnesses. In recent years, with the development of imaging technology and the continuous improvement of the brain network analyzing methods, the resting-state brain functional network researches shed a light on clinical diagnosis and treatment of diseases.