摘要
miRNA是一条19~23核苷酸的非编码RNA,在生物的生长,分化,细胞增殖,凋亡中起到了重要的作用。冠心病常常伴随病理性重塑反应,损伤心脏的收缩力,其中miRNA也起到重要作用。一些心脏特异性miRNA表现出冠心病的诊断价值。中医药在冠心病治疗中发挥着重要作用,通过中医药与miRNA的研究发现,miRNA很有可能成为中医药理论发展的重要研究对象,成为证候标志物及中药研发的新靶点。本文对miRNA做一简单介绍,重点阐述了miRNA在冠心病中的作用,其作为冠心病生物标志物的潜力以及它与中医药的密切联系。
miRNA,as a 19-23 nucleotide non-coding RNA,plays an important role in biological growth,differentiation,cell proliferation and apoptosis. miRNA played an important role in pathologic remodeling process of coronary artery disease( CAD) and injury in myocardial contractility. Further research found that some cardiacspecific miRNA exhibited certain a diagnostic value of diagnoses about CAD,which was closely associated with traditional markers. Traditional Chinese medicine( TCM) played an important role in treating coronary heart disease( CHD). According to studies on TCM and miRNA,miRNA is likely to be a new target for the theory development of TCM theory,and syndrome remarker and development RD of TCM. This paper gives a brief introduction of miRNA,and focuses on the role of miRNA as a potential biomarker for treating( CHD) and its close relationship with TCM.
出处
《中国实验方剂学杂志》
CAS
CSCD
北大核心
2015年第22期1-5,共5页
Chinese Journal of Experimental Traditional Medical Formulae
基金
国家自然科学基金项目(81473561
81173116)