基于数据挖掘的国医大师颜正华含桑寄生处方用药规律分析

Medication Rules of State Medical Master YAN Zheng-hua's Prescriptions with Taxilli Herba Based on Data Mining

目的:探讨国医大师颜正华教授含桑寄生处方用药规律。方法:在收集颜正华教授含桑寄生处方的基础上,基于中医传承辅助系统构建数据库,进而以关联规则Apriori算法为主要数据挖掘方法,分析、获取含桑寄生处方中单味药物频次、药物组合频次、关联规则与核心药物组合等。结果:含桑寄生处方常用于治疗眩晕、痹证、腰痛等病证,高频次药物包括赤芍、牛膝、白芍、丹参、续断等,高频次药物组合包括"赤芍、桑寄生","牛膝、桑寄生","白芍、桑寄生"等,置信度≥0.9的关联规则包括"牛膝->桑寄生","茯苓->桑寄生","桑枝->桑寄生","炒酸枣仁->桑寄生"等。结论:颜正华教授含桑寄生处方所用药物多具补益肝肾、活血化瘀止痛、祛风湿强筋骨之功,用药较为集中,组方法度清晰。

Objective： To explore the medication rules of state medical master YAN Zheng-hua＇s prescriptions with Taxilli Herba. Method： Prof. YAN Zheng-hua＇s prescriptions containing Taxilli Herba were collected to build a database based on Traditional Chinese Medicine Inheritance Support System （TCMISS）. Then the data were mainly analyzed by Apriori algorithm in TCMISS to acquire the frequency of single medicine, the frequency of drug combinations, the association rules and core drug combinations. Result： The prescriptions containing Taxilli Herba were commonly used to treat vertigo, arthromyodynia syndrome, lumbago and other syndromes. The frequently used drugs were Paeoniae Radix Rubra, Achyranthis Bidentatae Radix, Paeoniae Radix Alba, Salviae Mihiorrhizae Radix et Rhizoma, Dipsaei Radix, and so on. The frequently used drug combinations were ＇ Paeoniae Radix Rubra, Taxilli Herba＇ , ＇ Achyranthis Bidentatae Radix, Taxilli Herba＇ , and ＇ Paeoniae Radix Alba, Taxilli Herba＇. The drug association rules with a confidence of more than 0.9 included ＇ Achyranthis Bidentatae Radix- 〉 Taxilli Herba＇ , ＇ Poria- 〉 Taxilli Herba＇ , ＇ Mori Ramulus- 〉 Taxilli Herba＇ , and ＇ Fired Ziziphi Spinosae Semen-〉 Taxilli Herba＇, and so on. Conclusion： Prof. YAN Zheng-hua＇ s prescriptions containing Taxilli Herba mostly have the effects of nourishing liver and kidney, promoting blood circulation to remove blood stasis and relieve pain, expelling evil-wind, removing dampness, with concentrated medication and clear prescription principles.