基于数据挖掘的国医大师颜正华含牛膝处方用药规律分析

Analysis on Medication Rules of State Medical Master YAN Zheng-hua's Prescriptions with Achyranthis Bidentatae Radix Based on Data Mining

目的:探讨国医大师颜正华教授处方用药规律。方法:在收集相关处方的基础上,基于中医传承辅助系统构建数据库,进而利用该系统的数据分析模块中嵌入的关联规则Apriori算法为主要数据挖掘方法,分析并获得含牛膝处方中单味药物频次、药物组合频次、关联规则与核心药物组合等。结果:含牛膝处方常用于治疗眩晕、痹证、腰痛等病证,高频次药物包括赤芍、桑寄生、白芍、丹参、益母草等,高频次药物组合包括"牛膝、赤芍","牛膝、桑寄生","赤芍、桑寄生"等,置信度≥0.9的关联规则包括"续断->牛膝","白芍,桑寄生->牛膝","白芍,赤芍,桑寄生->牛膝"等。结论:颜正华教授含牛膝处方所用药物多具活血通络、补肝肾、强筋骨等功效,组方法度清晰严谨。

Objective： To explore the medication rules of State Medical Master YAN Zheng-hua＇s prescriptions with Achyranthis Bidentatae Radix. Method： The prescriptions including Achyranthis Bidentatae Radix that built by Pro. Yan were collected to build a database based on Traditional Chinese Medicine Inheritance Support System（ TCMISS）. Then the data were analyzed mainly by Apriori algorithm in the data analysis module of TCMISS to acquire the frequency of single medicine,the frequency of drug combinations,the association rules and core drug combinations in 441 prescriptions including Achyranthis Bidentatae Radix. Result： The prescriptions including Achyranthis Bidentatae Radix were commonly used to treat vertigo,rheumatism syndrome,lumbago and other syndromes. The highest frequency used drugs were Paeoniae Radix Rubra,Taxilli Herba,Paeoniae Radix Alba,Salviae Miltiorrhizae Radix et Rhizoma,Leonuri Herba,and so on. The most frequency drug combinations were ‘Achyranthis Bidentatae Radix,Paeoniae Radix Rubra＇,‘Achyranthis Bidentatae Radix,Taxilli Herba＇,and ‘Paeoniae Radix Rubra,Taxilli Herba＇and so on. when the the minimum-confidence was 0. 9,the drug association rules were ‘Dipsaci Radix- Achyranthis Bidentatae Radix＇,‘Paeoniae Radix Alba,Taxilli Herba-〉Achyranthis Bidentatae Radix＇,‘Paeoniae Radix Alba,Paeoniae Radix Rubra,Taxilli Herba-〉 Achyranthis Bidentatae Radix＇,and ‘Taxilli Herba- Achyranthis Bidentatae Radix＇,and so on. Conclusion： The drugs in the prescriptions containing Achyranthis Bidentatae Radix that built by Pro. Yan mostly had the effects of promoting blood circulation to remove meridian obstruction,invigorating the liver and kidney and strengthening muscles and bones,which reflected the clear and precise conception of composing formulas.