基于数据挖掘的中医治疗肝病处方用药规律分析

Medication Rules of Prescriptions of Hepatopathy Based on Data Mining

目的:探讨中医治疗肝病的用药规律。方法:收集治疗肝病处方,基于中医传承辅助系统软件构建数据库,进而采用关联规则Apriori算法和复杂系统熵聚类方法,确定处方中各药物和药物组合的使用频次及药物之间的关联规则等。结果:高频次药物包括茯苓、丹参、茵陈、白术、柴胡等;高频次药物组合包括"丹参、茯苓","白术、茯苓","丹参、赤芍"等;置信度为0.6以上的关联规则包括"黄芪->丹参","白术->茯苓","黄芪->茯苓","党参->茯苓"。结论:纳入研究治疗肝病的处方多用健脾渗湿、凉血活血、养阴柔肝、疏肝解郁之品,配伍精巧,符合中医标本兼治的用药原则。

Objective： To investigate the medication rules of traditional Chinese medicines（ TCM） for the treatment of hepatopathy by National Medical Masters. Method： The prescriptions for hepatopathy were collected to build a database based on TCM inheritance assist system. Apriori algorithm and complex system entropy cluster were adopted to determined the frequency of single medicine and drug combinations that used in prescriptions,and the association rules between drugs e. Result： Frequently used herbs included Poria,Salviae Miltiorrhizae Radix et Rhizoma,Artemisiae Scopariae Herba,Atractylodis Macrocephalae Rhizoma and Bupleuri Radix; Frequently used drug combinations included ‘Salviae Miltiorrhizae Radix et Rhizoma and Poria ＇,‘Atractylodis Macrocephalae Rhizoma and Poria＇and ‘Salviae Miltiorrhizae Radix et Rhizoma and and Paeoniae Radix Rubra ＇. The association rules with a confidence of above 0. 6 included ‘Astragali Radix- 〉Salviae Miltiorrhizae Radix et Rhizoma and＇,‘Atractylodis Macrocephalae Rhizoma-〉 Poria＇,‘Astragali Radix- 〉Poria＇and ‘Pilosula Codonopsis- 〉Poria＇. Conclusion： The prescriptions used for the treatment of hepatopathy mostly have the effects of reinforcing spleen and eliminating dampness,cooling blood and activating blood circulation,nourishing Yin to calm liver and discharging liver and relieving depression,with the refined compatibility and the TCM medication principles for treating symptoms and root causes.