基于文献挖掘的相恶药对“干姜与黄芩”配伍特点分析

Research on Features of Compatibility of the Antagonistic Combination of ‘Zingiberis Rhizoma and Scutellariae Radix' Based on Data Mining

目的:探讨相恶药对干姜与黄芩临床配伍应用规律。方法:系统检索干姜与黄芩配伍文献,应用Office 2007中Excel进行数据贮存和分析,对处方中干姜与黄芩配伍治疗的疾病、用药剂量、配伍比例、剂型等进行整理和分析。结果:干姜与黄芩配伍处方主要用于治疗内科疾病(878例,90%),其次是外科疾病(52例,5%),妇科疾病(17例,2%)等;内科疾病中脾胃系病证705例(占内科疾病总数的80%),肺系病证63例(占内科疾病总数的7%),肝胆疾病46例(占内科疾病总数的5%);黄芩用量以10,9,6,15 g居多,82%处方中的黄芩剂量在《中国药典》规定的范围内;干姜用量以10,6 g居多,95%处方中的干姜剂量在《中国药典》规定的范围内。干姜与黄芩配伍用量比例以1∶1最多(36%)。结论:相恶药对"干姜与黄芩"广泛应用于内、外、妇科等多种病证,两者寒热并举,相制而相成,适用于寒热错杂等病证。

Objective： To explore the rules of compatibility of the antagonistic combination of‘Zingiberis Rhizoma and Scutellariae Radix＇in clinical. Method： The prescriptions included the application of‘Zingiberis Rhizoma and Scutellariae Radix＇were systematically retrieved in databases,and the collation and analysis of related diseases,dosage,compatibility proportion and preparation formulation were analyzed by Excel of Microsoft 2007. Result： The prescriptions included the antagonistic combination of ‘Zingiberis Rhizoma and Scutellariae Radix＇were mainly used for the treatment of internal diseases（ 878 cases,90%）,which was followed by surgical diseases（ 52 cases,5%）,gynecological diseases（ 17 cases,2%）,and so on. In the internal diseases,the quantity of morbidity of spleen-stomach diseases was the most,which was accounted for 80%（ 705cases） of the total. Others were diseases of pulmonary system（ 63 cases,7%）,and diseases in the liver and gallbladder（ 46 cases,5%）. In the prescriptions,the dosages of Radix Scutellariae were primarily 10,9,6,15 g,82% of which were in the range provided by Chinese Pharmacopoeia. The dosages of Zingiberis Rhizoma were mainly 10 g and 6 g,95% of which were in the range provided by Chinese Pharmacopoeia. And the compatibility proportion of ‘Zingiberis Rhizoma and Scutellariae Radix＇ was mostly 1 to 1,which was accounted for 36%.Conclusion： The antagonistic combination of ‘Zingiberis Rhizoma and Scutellariae Radix＇was widely used in a variety of interior,exterior,gynaecology,paediatrics and other syndromes. The application of the antagonistic combination was proved have a satisfactory efficacy,though the two drugs have the contrary property.