核-壳型稀土上转换纳米材料的生物医学应用

Biomedical applications of lanthanide-doped upconversion core-shell nanostructures

稀土掺杂的上转换纳米粒子具有优越的物化性能,如光稳定性、连续发射能力以及锐利的多峰线发射,使其在生物医学领域具有广泛的应用前景.但是,传统上转换纳米粒子由于易发生表面猝灭效应,会大大降低量子产率,从而阻碍了其在生物医学领域的进一步发展.通过核壳结构的设计,不仅可以弥补传统上转换纳米粒子的固有缺陷,并且带来一系列革新的性能和广泛的应用.本文介绍了近几年研究较多的4种核-壳型上转换纳米粒子,分析总结它们的结构特点和研究现状,同时还调研了核壳结构在生物医学领域的最新研究进展,期望能够加深人们对这一领域的理解,为今后新型核壳结构的设计提供指导.

Lanthanide-doped upconversion nanoparticles possess superior physicochemical features such as excellent photostability, continuous emission capability, and sharp multi-peak line emission, which have been shown great potential applications in the biomedical field. However, the further development of conventional upconversion nanoparticles in the field of biomedical has been hindered by low upconversion efficiencies associated with surface quenching effect. The core-shell design of these nanostructures not only remedy the inherent defects of nanoparticles, but also bring a series of innovation performance and wide application. This review summarized four kinds of light upconverting core-shell nanostructures of most prevalence in recent years, as well as their structural characteristics and research status, and the latest research progress in the field of biomedical is reviewed in detail. It is anticipated that the present review will deepen people＇s understanding of this field and hence contribute to guide the future design of novel core-shell structures.