三维细胞培养技术在眼科领域的应用进展

The application progress of three-dimensional cell culture technology in ophthalmology

三维细胞培养技术是一种利用支架材料将体外细胞进行三维空间培养的技术,具有体内微环境模拟度高于二维平面细胞培养模式,可控性强于动物实验等优点.近年来,随着组织工程学技术的发展,各种生物学材料支架应运而生,为三维细胞培养技术提供了有利的平台.在眼科方面,三维细胞培养技术已应用于角膜、视网膜、视觉系统发育及多种眼肿瘤等方面的研究中.本文就三维细胞培养技术在眼科基础研究和临床疾病诊疗方面的应用进行综述.

Three-dimensional cell culture technology is a kind of technology that cultures the cells in a three-dimensional cultivation by using a kind of scaffold materials in vitro.Its advantage is that the vivo microenvironment simulating degrees of the three-dimensional culture technology is higher than that of the two-dimensional planar cell culture model, and the controllability is also higher than the animal experiment.In recent years, with the development of tissue engineering technology, a varietiy of the stent of biological materials also a fast development, which provided a favorable platform for three-dimensional cell culture technology.In ophthalmology, three-dimensional cell culture has been applied to the cornea, retina and the visual system development and other optic tumor researches.The objective of this paper is to making a review the application status of the three-dimensional cell culture technology in the basic research and clinical treatment in ophthalmology.