体重指数与左心房容积的相关性研究

Correlation between body mass index and left atrial volume

目的探讨体重指数与左心房容积（LAV）的相关性。方法人选首都医科大学附属北京同仁医院2012年1-4月接受超声心动图检查的门诊及住院患者，所有入选者测量身高、体质量，计算体重指数。采用经胸超声心动罔测量左心房内径、左心室后壁厚度、左心室舒张末期内径、左心室收缩末期内径、左心室缩短分数，采用双平面Simpson法测量左心室射血分数和LAV。采用单因素和多因素线性回归分析的方法评估体重指数与LAV的相关性。结果共入选476例患者，其中男268例（56．3％），女208例（43．7％）。按照体重指数25．0kg／m^2为切点将全部病例分为肥胖组（289例）和非肥胖组（187例），肥胖组的LAV明显高于非肥胖组[（26±6）ml比（24±7）m1]，差异有统计学意义（P〈0．01）。多元线性同归分析显示，校正其他因素后，体重指数与LAV呈正相关（β=0．37，P〈0．001），分别埘男性和女性进行统计分析后屁示，体重指数均与IAV呈正相关（男性：β=0．39，P〈0．001；女性：β=0．31，P=0．017）。结论在校正了左心室内径、后壁厚度等显著因素后，体重指数仍是LAV增大的独立危险因素，且与性别无关。

Objective To explore the correlation between body mass index （BMI） and left atrial volume （LAV）. Methods Patients undergoing transthoracic echocardiography from January 2012 to April 2012 were consecutively enrolled. The weight, height, and blood pressures were recorded; the left ventricular diameter （LVD）, left ventricular posterior wall thickness （LVPW）, left ventricular end diastolic diameter （LVEDD）, left ventricular end systolic diameter （LVESD）, left ventricular fractional shortening （LVFS） were measured by M-mode ultrasound; the left ventricular ejection fi＇action （LVEF） and left ventricular volume （LAV） were assessed by Simpson method. The correlations between BMI and LAY were analyzed. Results A total of 476 patients were finally enrolled, including 268 male and 208 female. The patients were divided into obesity group （BMI ≥ 25.0 kg/m^2, 289 cases） and non-obesity group （BMI 〈 25.0 kg/m^2, 187 cases） , the LAV in obesity group was significantly higher than that in non-obesity group [ （26 ±6） ml vs （24 ±7） ml] （P 〈0. 01 ）. Multivariate linear regression showed that BMI was significantly correlated with LAV after adjustment of other potential risk factors （β = 0.37, P 〈 0.001 ） ; in male and female, the same results were obtained （ male ：β= 0.39, P 〈 0.001 ; female ： β =0.31 ,P = 0. 017）. Conclusion BMI is an independent predictor of LAV increasing in both male and female.