依达拉奉联合血栓通在脑梗死患者治疗中的应用及对神经功能影响分析

Application of edaravone combined with Xueshuantong in treating cerebral infarction and it effect on neurological function

目的分析依达拉奉联合血栓通在脑梗死患者治疗中的应用及对神经功能的影响。方法选择2014年1月至2015年1月江苏省无锡市人民医院收治的100例脑梗死患者，按照人院顺序将患者分为观察组（50例）和对照组（50例）。对照组采用血栓通治疗，0．45g加入250ml0．9％氯化钠注射液中静脉滴注，1次／d，连续治疗2周。观察组在对照组的基础上给予依达拉奉治疗，30mg加入100ml0．9％氯化钠注射液中，与加有血栓通的0．9％氯化钠注射液一起进行静脉滴注，1次／d，连续治疗2周.比较2组患者的一股临床资料、临床疗效、神经功能缺损量表评分、日常生活能力指数评分。结果观察组患者治疗后总有效率明显高于对照组，差异有统计学意义[98．0％（48／50）比82．0％（41／50），P〈0．05]。治疗后1周及治疗后2周，观察组患者神经功能缺损量表评分均低于对照组，差异有统计学意义[（16．3±3．2）分比（23．6±4．8）分、（12．1±2．5）分比（17．6±3．2）分，P〈0．05]。治疗后1周及治疗后2周，观察组患者的日常生活能力指数评分均高于对照组，差异有统计学意义[（50±13）分比（41±11）分、（67±14）分比（51±11）分，P〈0．05]。结论依达托奉联合血栓通治疗啮梗死效果良好，能明显提高患者的神经功能以及日常生活能力。

Objective To analyze the application of edaravone combined with Xueshuantong in treating cerebral infarction and it effect on neurological function. Methods Totally 100 patients with cerebral infarction patients from January 2014 to January 2015 were enrolled and sequentially divided into observation group （50 cases） and control group （50 cases）. Control group was treated with Xueshuantong （0.45 g added in 250 ml 0.9% sodium chloride injection, intravenous drip, 1/d） ; observation group was treated with edaravone on the basis of therapy in control group （30 mg added in 100 ml 0. 9% sodium chloride injection） 1/d. The treatment was lasted for 2 weeks. The general clinical data, clinical efficacy, neurological impairment rating scale, daily living activity index score were compared between the two groups before and after treatment. Results The total effect rate in observation group was significantly higher than that in control group [ 98.0% （48/50） vs 82.0% （48/50）, P 〈 0.05] The nerve impairment scale score was significantly lower, the daily living activity index score was significantly higher in observation group than those in control group 1 week after treatment, [ （16.3±3.2） scores vs （23.6 ±4.8） scores, （12. 1 ±2.5） scores vs （17.6 ±3.2） scores] and 2 weeks after treatment [ （50 ±13） scores vs （41 ± 11） scores, （67 ±14） scores vs （51 ±11） scores] （P 〈 0.05）. Conclusion Edaravone combined with Xueshuantong has good clinical efficacy in treating cerebral infarction, it can significantly improve the neurological function and activity of daily living.