冠心病患者颈动脉内膜中层厚度、微量白蛋白尿与冠脉狭窄程度的相关性分析

The analysis of the correlation between coronary heart disease patients with carotid intima -media thickness, ;microalbuminuria and the degree of coronary artery stenosis

目的：观察冠心病患者尿微量白蛋白、颈动脉内膜中层厚度（CIMT）及冠脉 Gensini 评分水平，探讨冠脉狭窄程度与尿微量白蛋白、颈动脉内膜中层厚度的相关性。方法选取冠心病住院患者50例及健康对照组50例，比较两组间尿微量白蛋白、CIMT 及冠脉 Gensini 评分。结果冠心病组尿微量白蛋白、CIMT分别为（38．36±19．51）mg／L、（1．18±0．25）mm，健康对照组尿微量白蛋白、CIMT 分别为（27．52±15．44）mg／L、（0．76±0．17）mm，两组差异均有统计学意义（t ＝3．080，P ＝0．002；t ＝9．823，P ＝0．000），冠心病组冠脉 Gensini评分与尿微量白蛋白、CIMT 呈正相关（r ＝0．288，P ＝0．430；r ＝0．308，P ＝0．290）。结论冠心病患者尿微量白蛋白、CIMT 与冠脉狭窄程度呈正相关关系，通过测定尿微量白蛋白及颈动脉内膜中层厚度，可预测冠状动脉狭窄程度。

Objective To observe the microdose albumin in urine,carotid intima -media thickness（CIMT） of coronary heart disease（CHD）patients′and coronary Gensini score level,to investigate the correlation between the extent of coronary stenosis and microalbuminuria,CIMT.Methods 50 cases of hospitalized patients with CHD and healthy control group of 50 cases were selected,to compare the score between the two groups of microalbuminuria, CIMT and coronary Gensini.Results CHD group：microalbuminuria and CIMT were （38.36 ±19.51 ）mg/L, （1.18 ±0.25）mm respectively.Healthy control group：microalbuminuria and CIMT were （27.52 ±15.44）mg/L, （0.76 ±0.17）mm respectively.Differences between the two groups were statistically significant（t =3.080,P =0.002;t =9.823,P =0.000）.CHD group：coronary Gensini score was positively correlated with microalbuminuria, CIMT（r =0.288,P =0.430 r =0.308,P =0.290）.Conclusion The correlation between CHD patients＇microalbu-minuria,CIMT and the degree of coronary artery stenosis is positive.By measuring the microalbuminuria and CIMT,we can predict the extent of coronary artery stenosis.