轮状病毒肠炎患儿血常规变化及临床意义

The changes and clinical significance of routine blood test in infants with rotavirus enteritis

目的：探讨轮状病毒（RV）肠炎儿童血常规的变化及临床意义。方法对314例 RV 肠炎患儿（观察组）在治疗前和治疗5～7 d 后采血，用全自动血细胞分析仪测定血常规参数[白细胞计数（WBC）、血小板计数（PLT）、血小板体积（MPV）、血小板分布宽度（PDW）、]同时测定 CRP，并与对照组（40例）比较。结果治疗前观察组 WBC（10．77±4．20）×109／L、PLT（330．02±117．70）×109／L、MPV（8．46±2．15）fL，均高于对照组[WBC（7．69±2．06）×109／L、PLT（298．45±57．19）×109／L、MPV（7．52±0．85）fL，t ＝4．569、1.670、2．746，P ＝0．000、0．000、0．047]，差异均有统计学意义。治疗后观察组 WBC（7．76±2．83）×109／L、CRP（5.18±5．82）mg／L，均较治疗前[WBC（10．77±4．20）×109／L、CRP（7．70±11．28）mg／L]降低，差异均有统计学意义（t ＝9．794、2．810，均 P ＝0．000）。结论儿童 RV 肠炎常见 WBC、PLT、CRP 增高，不能单纯以WBC 和 CRP 增高作为腹泻患儿应用抗生素的指征。

Objective To investigate the changes and clinical significance of routine blood test in infants with rotavirus enteritis.Methods The white blood cell count （WBC）,the platelet parameters （PLT）,the platelet volume （MPV）and the platelet distribution width （PDW）were detected by automatic blood cell analyzer respectively in 314 infants with rotavirus enteritis before and after the therapy for 5 -7 days.The C -reactive protein （CRP）was also detected,then made comparison with the normal control group （40 cases）.Results The WBC （10.77 ±4.20）× 109 /L,PLT（330.02 ±117.70）×109 /L,MPV（8.46 ±2.15）fL in the infants with rotavirus enteritis were higher than the WBC（7.69 ±2.06）×109 /L,PLT（298.45 ±57.19）×109 /L and MPV（7.52 ±0.85）fL in the control group before the therapy.The differences were statistically significant （t value =4.569,1.670,2.746,P =0.000, 0.000 and 0.047）.The WBC（7.76 ±2.83）×109 /L and CRP（5.18 ±5.82）mg/L in the infants with rotavirus enteritis after the therapy were lower than the WBC（10.77 ±4.20）×109 /L and CRP（7.70 ±11.28）mg/L before the therapy（t value =9.794 and 2.810,P =0.000）.Conclusion The WBC,PLT and CRP in infants with rotavirus enteritis were usually higher.But the raise of WBC and CRP could not be the only indication of using antibiotic in infants suffered from diarrhea.