低频重复经颅刺激联合药物干预对精神分裂症患者顽固性幻听和认知功能的影响效果探析

Investigative effects of low frequency repetitive transcranial magnetic stimulation combined with drugs on obstinate auditory hallucinations and cognitive function in patients with schizophrenia

目的观察低频重复经颅刺激联合药物干预对精神分裂症患者顽固性幻听和认知功能的影响效果。方法选择128例精神分裂症患者,随机分为观察组与对照组,分别予以低频重复经颅刺激及利培酮治疗,单纯利培酮治疗,观察两组患者治疗前后幻听以及认知功能的改善情况。结果治疗前,两组患者的AHRS评分、VFT评分、B连线时间、B错误数以及B提笔数均无明显差异,具有可比性(P>0.05)。治疗后,观察组AHRS评分低于对照组,VFT评分则升高明显,差异具统计学意义(P<0.05)。结论低频重复经颅刺激联合药物干预可较好的改善精神分裂症患者顽固性幻听,以及语言方面的认知功能。

Objective To explore the clinical value of low frequency repetitive transcranial magnetic stimulation in improving obstinate auditory hallucinations and cognitive function in patients with schizophrenia.Methods According to visiting order number,128 patients with schizophrenia were divided into control group and observation group. The observation group was treated by low frequency repetitive transcranial magnetic stimulation combined with risperidone,the control group was treated with risperidone. Before and after treatment,the patients were evaluated,by auditory hallucinations rating scale（ AHRS） and assessment of verbal fluency and trail making were performed in patients. Results There was no significant difference in AHRS scores,VFT scores and trail making between the two groups before treatment（ P〈0. 05）. After treatment,the AHRS scores in the observation group were lower than that in the control group,the VFT scores in the observation group were higher than that in the control group,with statistical significance between two groups（ P〈0. 05）. Conclusions Low frequency repetitive transcranial magnetic stimulation can effectively improve obstinate auditory hallucinations in patients with schizophrenia,and has certain effect in improving their cognitive function.