摘要
目的探讨替格瑞洛在冠心病患者中的应用,分析护理效果。方法将入选的50例ACS患者按治疗方式不同分为两组,每组各25例,在常规治疗方案基础上,氯吡格雷组采用氯吡格雷进行抗血小板,替格瑞洛组采用替格瑞洛进行抗血小板,两组患者用药后给予及全面的临床护理干预:住院期间加强宣教,普及疾病相关知识,进行心理干预;出院后严密随访病情、不良反应,加强健康指导,强调家庭支持干预。对两组患者的服药依从性、心血管事件及药物不良反应发生情况进行统计分析。结果替格瑞洛组依从性好于氯吡格雷组(χ2=4.905;P<0.05),两组患者缺血事件发生率无统计学差异(χ2=0.312;P>0.05),两组患者不良反应发生情况均无统计学差异(χ2=0.622;P>0.05)。结论替格瑞洛对ACS患者具有显著疗效,预防心脏缺血事件及不良反应率不劣于氯吡格雷。护理干预能有效提高患者依从性,为临床研究的顺利进行提供护理保障。
Objective To explore the application of ticagrelor in patients with coronary heart disease and analysis the nursing effect. Methods 50 ACS patients were enrolled,divided into two groups. Based on conventional therapy,clopidogrel group with clopidogrel antiplatelet,ticagrelor group was given by ticagrelor platelet. Both groups giving the comprehensive clinical nursing intervention. Strengthening health education during hospitalization,spread of disease related knowledge,psychological intervention; Careful follow-up the disease,the adverse reaction after discharge, enhancing health education, emphasis on family support intervention,analyzed the two groups of patients with medication compliance,cardiovascular events and adverse drug reaction. Results Clopidogrel group exhibited better medication compliance than ticagrelor group（ χ2= 4.905; P〈0. 05）. Incidence of ischemic event without statistically significant difference（ χ2= 0. 312; P〈0. 05）.The incidence of adverse reactions were not statistically different（ χ2= 0. 622; P〈0. 05）. Conclusions Ticagrelor has obvious therapeutic effect on ACS patients,prevention of cardiac ischemic events and adverse reaction rate is not inferior to clopidogrel. Nursing intervention can improve the compliance of patients,to provide nursing support for the clinical study smoothly.
出处
《齐齐哈尔医学院学报》
2015年第30期4654-4656,共3页
Journal of Qiqihar Medical University
