热性惊厥患儿心肌损伤的临床观察

Clinical observation on cardiac muscle injury of children with febrile convulsion

目的通过测定热性惊厥患儿的心肌酶谱,了解单纯性FC与复杂性FC发作后心脏损伤情况。方法将2013年7月至2014年11月本院收治的97例由急性上呼吸道感染导致的热性惊厥患儿分组。其中,72例单纯性热性惊厥患儿分入单纯性热性惊厥组,25例复杂性热性惊厥患儿分入复杂性热性惊厥组。将同期单纯上呼吸道感染患儿30例分入对照组,对所有患儿进行心肌酶谱检测。结果单纯性热性惊厥组、复杂性热性惊厥组的血清肌酸激酶(CK),血清肌酸激酶同工酶(CK-MB)水平较对照组均明显升高,且复杂性热性惊厥组较单纯性热性惊厥组升高更为明显;单纯热性惊厥组与对照组相比,血清缺血修饰白蛋白(IMA)水平无明显升高,而复杂性热性惊厥组IMA水平比单纯热性惊厥组与对照组均明显升高。结论热性惊厥发作可引起心肌损伤,复杂性热性惊厥更为明显,对热性惊厥患儿应及早行心肌酶谱检查,必要时进行积极的干预治疗。

Objective To explore the myocardial injury by measuring cardiac muscle zymogram in children with simple febrile seizures（ SFS） and complex febrile seizures（ CFS）. Methods From July,2013 to November,2014,97 patients with febrile seizures（ FS） caused by acute upper respiratory infection were divided into simple febrile seizures group（ SFS group,72 patients） and complex febrile seizures group（ CFS group,25 patients）,and 30 patients only with upper respiratory infection were divided into control group. The cardiac muscle zymogram was measured among all of children. The results of three groups were compared. Results Compared with control group,the serum level of creatine kinase（ CK）,the creatine kinase- MB（ CK- MB） in SFS and CFS groups were significantly increased,and CK and CK- MB in CFS group were increased more significantly compared with SFS group. Compared with the control group,the serum level of ischemia modified albumin（ IMA） in SFS group had no significant increasing. However,IMA in CFS group increased significantly compared with the SFS group and control group. Conclusions FS could cause myocardial injury in children,and CFS will be more serious. Thus,early examination of cardiac muscle zymogram for children with FS should be performed and intervention therapy for FS is also necessary.