氧化苦参碱对晚期肝癌患者AFP、CEA和CA125影响研究

Effects of AFP,CEA and CA125 by oxidation of Matrine in advanced liver cancer patients

目的:探讨氧化苦参碱对晚期肝癌患者AFP、CEA和CA125的影响。方法:选取我院收治的晚期肝癌患者158例,根据治疗方法的不同,分为两组,对照组79例,予常规治疗葡萄糖醛酸内酯,还原型谷胱甘肽,维生素K1,等普通护肝药物治疗。治疗组79例,在对照组的基础上加以氧化苦参碱注射液20mL溶于200mL生理盐水中,1d1次静滴,7d为1个疗程,治疗2个疗程。治疗后,观察并比较两组患者的肝功能情况,AFP、CEA和CA125的变化以及患者的生存情况。结果:与对照组相比较,治疗组的肝功能明显改善(P<0.05),AFP、CEA和CA125显著降低(P<0.05),生存时间明显延长(P<0.05)。结论:氧化苦参碱能够改善晚期肝癌患者的肝功能,降低AFP、CEA和CA125,延长患者的生存时间。

Objective：To investigate the effect of AFP,CEA and CA125 by oxidation of Matrine in advanced liver cancer patients.Methods：158advanced liver cancer patients from our hospital were selected and divided into the control group 79 cases and the experiment group 79 cases by different treatment.The control group were treated by glucuronic acid,glutathione,vitamin K1,and other common liver protecting medicine.The treatment group were treated on the base of the control group with the oxidation of Matrine.The liver function,changes of AFP,CEA and CA125,and survival of patients were observed and compared after treatment.Results：Compared with the control group,the liver function were better（P〈0.05）,the AFP,CEA and CA125 were lower（P〈0.05）,the survival time were longer（P〈0.05）.Conclusion：Oxidation of Matrine can improve the liver function of patients with advanced liver cancer,reduce the AFP,CEA and CA125,so as to prolong the survival time of patients,it is worthy of clinical application.