玻璃体腔注射曲安奈德联合复方血栓通胶囊治疗糖尿病性黄斑水肿的疗效观察

The effect of intravitreal injection of triamcinolone acetonide combined with compound Xueshuantong capsule in the treatment of diabetic macular edema

目的探讨玻璃体腔注射曲安奈德联合复方血栓通胶囊治疗糖尿病性黄斑水肿的疗效。方法选取广州市白云区红十字会医院58例(108眼)糖尿病性黄斑水肿(DME)患者为研究对象,采用简单抽样法随机分成治疗组(A组)和对照组(B组)两组,各54眼。其中A组采用玻璃体腔内注射曲安奈德联合复方血栓通胶囊口服,B组仅于玻璃体腔内注射曲安奈德。观察两组黄斑中心凹厚度(行光学相干断层成像检查测量)以及视力变化。结果1治疗3个月后,两组检查均较治疗前明显变薄,A组为(275.36±79.25)μm,明显薄于B组的(307.31±80.37)μm,P<0.05;治疗6个月后,A组持续变薄至(253.27±78.26)μm,B组则增厚至(362.26±81.47)μm,两组对比有统计学意义(P<0.05);治疗6个月后,A组视力水平持续提升至(0.27±0.15),B组则降至(0.19±0.10),组间对比差异明显(P<0.05)。结论对DME患者给予玻璃体腔注射曲安奈德联合复方血栓通胶囊方案,疗效较显著,值得临床推广。

Objective：To investigate the efficacy of intravitreal injection of triamcinolone acetonide combined with Fu-fang Xueshuantong Capsule in the treatment of diabetic macular edema. Methods：Fifty-eight patients（108 eyes）who met the diagnose criteria of diabetic macular edema（ DME）were randomly divided into the treatment group（ Agroup）and con-trol group（ B group）. The A group received intravitreal injection of triamcinolone acetonide combined with Fufang Xue-shuantong Capsule,group B only received intravitreal injection of triamcinolone acetonide. We observed the thickness（ by optical coherence tomography measurements）and the changes of vision sight in both of the two groups. Results：After 3 months of treatment,two groups showed significantly change. The thickness in the group A（275. 36 ± 79. 25）μm was sig-nificantly thinner than that in group B（307. 31 ± 80. 37）μm,（P﹤0. 05）;after 6 months of treatment,the thickness in the group A reduced to（253. 27 ± 78. 26）μm,while that in the group B was（362. 26 ± 81. 47）μm,the horizontal com-parison was statistically significant（P﹤0. 05）;after 6 months treatment,vision sight level in the group A rose to（0. 27 ± 0. 15）,which was much better than that of the group B（0. 19 ± 0. 10）（P﹤0. 05）. Conclusion：The clinical efficiency of intravitreal injection of triamcinolone acetonide combined with Fufang Xueshuantong Capsule on patients with DME is re-markable,which is worth further clinical study and promotion.