摘要
微小核糖核酸(microRNA,miRNA)是一类内源性非编码调控RNA,由二十几个核苷酸长度组成,其通过抑制蛋白质翻译或降解mRNAs调控基因转录后的表达,参与调节细胞的分化,增殖及凋亡,并在肿瘤的发生发展中起重要作用。研究表明乙型肝炎病毒和宿主之间通过miRNA进行相互调节,这在HBV相关肝病的发生发展中起着非常重要的作用。本文就miRNA与HBV感染及其相关肝病的研究现状加以综述以探讨miRNA的研究对HBV相关肝病诊治的重要意义。
MicroRNA（miRNA） is a type of endogenous regulation of non-codingRNA which is made up of more than 20 nucleotides in length. MiRNA involves in the regulation of cell differentiation,proliferation and apoptosis by inhibiting the expression of protein translation or degrading mRNAs to regulate gene transcription.It plays an important role in the occurrence and development of cancer. Studies have shown that the hepatitis B virus（HBV） and its host carry out mutual adjustment through miRNA. It is very important in the occurrence and development of HBV-related liver disease. In this paper, the research status of miRNA and HBV infection will be reviewed to discuss the importance of miRNA on diagnosis and treatment of HBV-related liver disease.
出处
《分子诊断与治疗杂志》
2015年第6期422-426,共5页
Journal of Molecular Diagnostics and Therapy
基金
国家科技重大专项(2012ZX10002005)
