单药卡培他滨在30例III期乳腺癌中辅助化疗的临床应用分析

Clinical Efficacy and Adverse Effects of Capecitabine in Patients With Stage III Breast Cancer as Adjuvant Chemotherapy

目的观察单药卡培他滨治疗30例70岁以上III期乳腺癌患者的不良反应及疗效,为临床治疗提供依据。方法回顾性分析2008年1月~2015年6月我院30例70岁以上乳腺癌患者术后给予单药卡培他滨方案治疗的资料。卡培他滨用法：每日口服卡培他滨1 000 mg/m2,21天为1个治疗周期,共6个周期,观察每次化疗后的毒副反应,完成6个疗程后门诊随访。结果 26例按计划完成疗程,2例因严重的手足综合征未完成疗程,最长随访时间90个月,局部复发4例,远处转移4例,因乳腺癌死亡3例,其他原因死亡4例,主要毒副反应为手足综合征、乏力、骨髓抑制等。结论单药卡培他滨治疗70岁以上乳腺癌疗效好,不良反应可以耐受,作为术后辅助化疗是安全有效的。

Objective To observe adverse effects and efficacy of 30 elder patients（more than 70 years old）diagnosed with stage III breast cancer after taking capecitabine alone. Methods 30 patients of breast cancer with more than 70 years old and pathologically proved,who received capecitabine alone after surgery from January 2008 to June 2015 in our institute. Daily oral administration of capecitabine 1 000 mg/m2,21 days for 1 treatment cycles,a total of 6 cycles. Adverse effects after each cycle were observed and evaluation were conducted after 6 cycles during follow up. Results 26 patients finished the whole course of chemotherapy as planned. The longest follow-up time was 90 months. 4 patients had local recurrence,and 4 patients had distant metastasis. 3 patients died of breast cancer,and 4 patients died of other reasons. The most common adverse effects were hand-foot syndrome,weakness, myelosuppression and so on. Conclusion The efficacy of capecitabine alone for more than 70 years old breast cancer patients was satisfied. Adverse effects were well tolerated. Capecitabine alone as adjuvant chemotherapy is safe and feasible.