曲美他嗪治疗稳定型心绞痛的效果研究

Study on Trimetazidine Effect in Treatment of Stable Angina

目的对曲美他嗪应用于稳定型心绞痛患者中的临床效果进行分析研究。方法选取于2013年8月~2015年7月经临床确诊并且在我院接受治疗的稳定型心绞痛患者67例,并随机分为常规治疗组（32例）和曲美他嗪组（35例）,观察并比较两种不同治疗方式的效果并比较。结果曲美他嗪组患者的治疗显效率为82.9%,治疗总有效率为94.3%,高于常规治疗组患者的43.8%和75%;同时曲美他嗪组患者的心绞痛发作次数以及硝酸甘油用量均少于常规治疗组,平板运动试验运动持续时间显著长于常规治疗组,组间差异经t检验,有统计学意义（P〈0.05）。结论曲美他嗪应用于稳定型心绞痛患者中的临床效果良好,能够减少硝酸甘油用量,对减少心绞痛发作次数具有十分重要的作用。

Objective Clinical effect of Trimetazidine in treatment of stable angina is to be studied. Methods Choose 67 patients with stable angina who are treated in hospital from August 2013 to July 2015 and separate them into Conventional Treatment Group（32 patients） and Trimetazidine Group（35 patients） at random; and then observe and compare treatment effects between two groups. Results Patients＇ explicit efficiency and treatment efficacy in Trimetazidine Group are 82.9% and 94.3% respectively, which are higher than counterparts of 43.8% and 75% in Conventional Treatment Group; besides, patients＇ angina attack times and their glycerin trinitrate consumption in Trimetazidine Group are less than those in Conventional Treatment Group, and patients＇ duration time of treadmill exercise testing is longer in Trimetazidine Group compared to that in Conventional Treatment Group. There is a differential between two groups and such a differential has statistic value according to T-Check（P 0.05）. Conclusion Trimetazidine is effective in treatment of stable angina; it is conducive to reducing glycerin trinitrate consumption, which is significant to decreasing patients＇ angina attack times.