吗替麦考酚酯对弥漫增生性狼疮性肾炎的诱导治疗疗效

Effect of Mycophenolate Mofetil Induction Therapy in Patients with Diffuse Proliferative Lupus Nephritis

目的分析吗替麦考酚酯诱导对弥漫增生性狼疮性肾炎效果。方法将76例患者分为两组各38例,A组患者经激素联合吗替麦考酚酯治疗,B组患者经间断静脉环磷酰胺治疗。结果 A组3个月总缓解率84.2%,6月总缓解率94.7%;B组3个月总缓解率55.3%,6月总缓解率76.3%,P<0.05;A组血白细胞降低发生率5.3%低于B组发生率21.1%,P<0.05;其余不良反应对比,P>0.05。结论吗替麦考酚酯诱导治疗弥漫增生性狼疮性肾炎缓解率高。

Objective To analyze mycophenolate mofetil induced diffuse proliferative lupus nephritis effect. Methods 76 patients were divided into two groups of 38 cases, A group of patients with hormone combined with mycophenolate mofetil therapy, group B patients with intermittent intravenous cyclophosphamide therapy. Results A group of three-month overall response rate 84.2%, in June overall response rate was 94.7%; group B 3 months, overall response rate of 55.3% in June overall response rate 76.3%,P 0.05; A group of white blood cells reduce the incidence rate 5.3% lower than the incidence of group B 21.1%,P 0.05; the rest of adverse reactions contrast,P 0.05. Conciusion Mycophenolate mofetil induced treatment of diffuse proliferative lupus nephritis remission rate.