喹硫平在老年痴呆精神行为症状治疗中的应用研究

Application Study on Quetiapine in Treatment of Mental and Behavioral Symptoms of Senile Dementia

目的对喹硫平应用于老年痴呆精神行为症状临床治疗中的效果进行分析研究。方法选取于2013年11月~2015年6月期间经临床确诊并且在我院接受治疗的老年痴呆精神行为症状患者60例,并随机分为利培酮组（28例）和喹硫平组（32例）,观察并比较利培酮和喹硫平的治疗效果。结果喹硫平组患者的基本痊愈率为50%,治疗总有效率为90.6%,高于利培酮组的25%和71.4%;同时喹硫平组患者的行为紊乱、焦虑恐慌、偏执、攻击行为等BEHAVE-AD各因子评分均低于利培酮组,组间差异经t检验,具有统计学意义（P〈0.05）。结论喹硫平用于老年痴呆精神行为症状临床治疗中的效果确切。

Objective Quetiapine application effect in treatment of mental and behavioral symptoms of senile dementia is to be studied. Methods Choose 60 patients of senile dementia who are treated in hospital from November 2013 to June 2015 and separate them into Risperidone Group（28 patients） and Quetiapine Group（32 patients） at random, and then observe and compare treatment effects of Risperidone and Quetiapine between two groups. Results Patients＇ cured rate and treatment efficacy in Quetiapine Group are 50% and 90.6% respectively, which are much higher than 25% and 71.4% in Risperidone Group; besides, patients＇ BEHAVE-AD score for each factor in Quetiapine Group, including behavior disorder, panic anxiety, paranoia and aggression, is lower than counterparts in Risperidone Group; there is a differential between two groups according to T-check and such a differential has statistic value（P 0.05）. Conclusion Quetiapine treatment is clinically effective for mental and behavioral symptoms of senile dementia.