盐酸利托君与硫酸镁治疗早产的疗效与安全性比较

Comparison of the Efficacy and Safety of Ritodrine Hydrochloride and Magnesium Sulfate in Treating Premature

目的探究采用盐酸利托君与硫酸镁对于早产的临床疗效和安全性情况。方法选择我院2014年4月~2015年4月收治的82例先兆早产孕妇,随机分为观察组和对照组,各41例。对照组采取硫酸镁治疗,观察组采取盐酸利托君治疗,对比两组保胎成功率、胎儿出生体重等临床指标情况。结果观察组保胎成功率高于对照组,差异有统计学意义（P〈0.05）;观察组胎龄延长时间、出生体重和Apgar评分高于对照组,差异有统计学意义（P〈0.05）。结论相比于硫酸镁治疗,盐酸利托君治疗早产具有较高的临床效果,能够显著提高保胎成功率,临床应密切监测产妇药物使用情况,确保产妇及新生儿健康。

Objective To investigate the use of ritodrine hydrochloride and magnesium sulfate for clinical efficacy and safety of premature labor situation. Methods We selected 82 cases of threatened premature labor in pregnant women from April 2014 to April 2015 in our hospital. They were randomly divided into observation group and control group, each group of 41 cases.. The control group took the magnesium sulfate treatment,while the observation group took ritodrine hydrochloride treatment.We compared clinical indicators of the successful rate of miscarriage and the fetal birth weight in the two groups. Results The successful rate of miscarriage of observation group was significantly higher than that of the control group. The difference was statistically significant（P 0.05）; The prolonged gestational age, birth weight and Apgar scores in the observation group were apparently higher than the control group,and the difference was statistically significant（P 0.05）. Conclusion Comparing to the magnesium sulfate treatment, hydrochloric acid ritodrine in treatment of premature labor is with high clinical effect. it can significantly improve the successful rate of miscarriage, and should be closely monitored clinical maternal drug use so as to ensure that maternal and newborn health.