息风平肝合益肺固卫方对小儿多发性抽动症细胞免疫功能的影响

Impact of Xifengpinggan Heyifeiguwei Prescription on Cellular Immune Function in Treating Pediatric Tourette Syndrome

目的观察息风平肝合益肺固卫方对小儿多发性抽动症(TS)阳亢风动、肺虚卫疏证的患儿治疗前后细胞免疫功能的影响,探讨其治疗小儿多发性抽动症的作用机理。方法对31例阳亢风动、肺虚卫疏证TS患儿予以息风平肝合益肺固卫方治疗8周,分别检测TS患儿治疗前后和30例健康儿童T淋巴细胞亚群水平。结果治疗组与健康对照组比较,CD3+、CD4+、CD4+/CD8+水平降低,CD8+水平上升,两组间差异有统计学意义(P<0.01);治疗后CD3+、CD4+、CD4+/CD8+水平上升,较治疗前升高(P<0.01),其中CD3+、CD4+已与正常体检儿童无差异。结论 TS的发病与机体的细胞免疫功能紊乱有关。息风平肝合益肺固卫方能有效地持续改善小儿多发性抽动症阳亢风动、肺虚卫疏证的临床症状,可能系通过调节细胞免疫功能达到治疗作用。

Objective To explore the mechanism of Xifengpinggan Heyifeiguwei prescription in treating pediatric tourette syndrome with Yang hyperactivity and Wind stirring, Lung and Wei deficiency syndrome by observing its impact on cellular immune function. Methods A group of 31 children with TS and another group of 30 healthy children were included in the research. The TS group were treated with Xifengpinggan plus Yifeiguwei prescription for 8 weeks. T-cell subpopulation were detected in both TS group（before and after the therapy） and healthy control group. Results（1）Compared with the healthy control group, the levels of CD3＋、CD4＋、CD4＋/CD8＋were significantly reduced and the level of CD8＋ was significantly increased in TS group pretherapy（P 0.01）.（2）The level of CD3＋、CD4＋、CD4＋/CD8＋increased after therapy（P 0.01）, and especially there were no significant differences in the level of CD3＋、CD4＋ between the TS group and the healthy control group. Conclusion The effect of Xifengpinggan plus Yifeiguwei prescription in treating children with TS may due to its regulation in cellular function.